Nitro-Mannich/lactamization cascades for the direct stereoselective synthesis of pyrrolidin-2-ones.
An efficient three-component nitro-Mannich/lactamization cascade of methyl 3-nitropropanoate with in situ formed acyclic imines for the direct preparation of pyrrolidinone derivatives has been developed. The reaction is easy to perform, broad in scope, and highly diastereoselective and may be extend...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1797083008693436416 |
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| author | Pelletier, S Ray, P Dixon, D |
| author_facet | Pelletier, S Ray, P Dixon, D |
| author_sort | Pelletier, S |
| collection | OXFORD |
| description | An efficient three-component nitro-Mannich/lactamization cascade of methyl 3-nitropropanoate with in situ formed acyclic imines for the direct preparation of pyrrolidinone derivatives has been developed. The reaction is easy to perform, broad in scope, and highly diastereoselective and may be extended to cyclic imines allowing the direct formation of polycyclic pyrrolidinone derivatives. |
| first_indexed | 2024-03-07T01:36:01Z |
| format | Journal article |
| id | oxford-uuid:9537c77f-3cbe-4344-880b-7667186225df |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:36:01Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:9537c77f-3cbe-4344-880b-7667186225df2022-03-26T23:44:41ZNitro-Mannich/lactamization cascades for the direct stereoselective synthesis of pyrrolidin-2-ones.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9537c77f-3cbe-4344-880b-7667186225dfEnglishSymplectic Elements at Oxford2009Pelletier, SRay, PDixon, DAn efficient three-component nitro-Mannich/lactamization cascade of methyl 3-nitropropanoate with in situ formed acyclic imines for the direct preparation of pyrrolidinone derivatives has been developed. The reaction is easy to perform, broad in scope, and highly diastereoselective and may be extended to cyclic imines allowing the direct formation of polycyclic pyrrolidinone derivatives. |
| spellingShingle | Pelletier, S Ray, P Dixon, D Nitro-Mannich/lactamization cascades for the direct stereoselective synthesis of pyrrolidin-2-ones. |
| title | Nitro-Mannich/lactamization cascades for the direct stereoselective synthesis of pyrrolidin-2-ones. |
| title_full | Nitro-Mannich/lactamization cascades for the direct stereoselective synthesis of pyrrolidin-2-ones. |
| title_fullStr | Nitro-Mannich/lactamization cascades for the direct stereoselective synthesis of pyrrolidin-2-ones. |
| title_full_unstemmed | Nitro-Mannich/lactamization cascades for the direct stereoselective synthesis of pyrrolidin-2-ones. |
| title_short | Nitro-Mannich/lactamization cascades for the direct stereoselective synthesis of pyrrolidin-2-ones. |
| title_sort | nitro mannich lactamization cascades for the direct stereoselective synthesis of pyrrolidin 2 ones |
| work_keys_str_mv | AT pelletiers nitromannichlactamizationcascadesforthedirectstereoselectivesynthesisofpyrrolidin2ones AT rayp nitromannichlactamizationcascadesforthedirectstereoselectivesynthesisofpyrrolidin2ones AT dixond nitromannichlactamizationcascadesforthedirectstereoselectivesynthesisofpyrrolidin2ones |