The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia.
Focal cortical dysplasia (FCD) is the most common malformation of cortical development found in epilepsy surgical series. Characterised by cortical mislamination, dysplastic neurons and, in a subgroup of cases, balloon cells, FCD is potently epileptogenic. Despite decades of study, the underlying ae...
| मुख्य लेखकों: | , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
2008
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| _version_ | 1826285924341776384 |
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| author | Sen, A Thom, M Nikolić, M Sisodiya, S |
| author_facet | Sen, A Thom, M Nikolić, M Sisodiya, S |
| author_sort | Sen, A |
| collection | OXFORD |
| description | Focal cortical dysplasia (FCD) is the most common malformation of cortical development found in epilepsy surgical series. Characterised by cortical mislamination, dysplastic neurons and, in a subgroup of cases, balloon cells, FCD is potently epileptogenic. Despite decades of study, the underlying aetiology of FCD remains uncertain and research has been hampered by the lack of a good animal model in which to simulate the condition. In this article we review some of the potential molecular mechanisms that might underpin human FCD. In particular we examine the potential role of cyclin-dependent kinase 5 and its principal activator p35 in FCD and estimate the contribution that deregulation of cyclin-dependent kinase 5 might make to the pathogenesis of this condition. |
| first_indexed | 2024-03-07T01:36:07Z |
| format | Journal article |
| id | oxford-uuid:953c79ab-5013-4414-ade8-09589c853b31 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:36:07Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:953c79ab-5013-4414-ade8-09589c853b312022-03-26T23:44:50ZThe potential role of cyclin-dependent kinase 5 in focal cortical dysplasia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:953c79ab-5013-4414-ade8-09589c853b31EnglishSymplectic Elements at Oxford2008Sen, AThom, MNikolić, MSisodiya, SFocal cortical dysplasia (FCD) is the most common malformation of cortical development found in epilepsy surgical series. Characterised by cortical mislamination, dysplastic neurons and, in a subgroup of cases, balloon cells, FCD is potently epileptogenic. Despite decades of study, the underlying aetiology of FCD remains uncertain and research has been hampered by the lack of a good animal model in which to simulate the condition. In this article we review some of the potential molecular mechanisms that might underpin human FCD. In particular we examine the potential role of cyclin-dependent kinase 5 and its principal activator p35 in FCD and estimate the contribution that deregulation of cyclin-dependent kinase 5 might make to the pathogenesis of this condition. |
| spellingShingle | Sen, A Thom, M Nikolić, M Sisodiya, S The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia. |
| title | The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia. |
| title_full | The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia. |
| title_fullStr | The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia. |
| title_full_unstemmed | The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia. |
| title_short | The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia. |
| title_sort | potential role of cyclin dependent kinase 5 in focal cortical dysplasia |
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