The fecal metabolome as a functional readout of the gut microbiome
The human gut microbiome plays a key role in human health1, but 16S characterization lacks quantitative functional annotation2. The fecal metabolome provides a functional readout of microbial activity and can be used as an intermediate phenotype mediating host–microbiome interactions3. In this compr...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Publishing Group
2018
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| _version_ | 1826285930621698048 |
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| author | Zierer, J Jackson, M Kastenmüller, G Mangino, M Long, T Telenti, A Mohney, R Small, K Bell, J Steves, C Valdes, A Spector, T Menni, C |
| author_facet | Zierer, J Jackson, M Kastenmüller, G Mangino, M Long, T Telenti, A Mohney, R Small, K Bell, J Steves, C Valdes, A Spector, T Menni, C |
| author_sort | Zierer, J |
| collection | OXFORD |
| description | The human gut microbiome plays a key role in human health1, but 16S characterization lacks quantitative functional annotation2. The fecal metabolome provides a functional readout of microbial activity and can be used as an intermediate phenotype mediating host–microbiome interactions3. In this comprehensive description of the fecal metabolome, examining 1,116 metabolites from 786 individuals from a population-based twin study (TwinsUK), the fecal metabolome was found to be only modestly influenced by host genetics (heritability (H2) = 17.9%). One replicated locus at the NAT2 gene was associated with fecal metabolic traits. The fecal metabolome largely reflects gut microbial composition, explaining on average 67.7% (±18.8%) of its variance. It is strongly associated with visceral-fat mass, thereby illustrating potential mechanisms underlying the well-established microbial influence on abdominal obesity. Fecal metabolic profiling thus is a novel tool to explore links among microbiome composition, host phenotypes, and heritable complex traits. |
| first_indexed | 2024-03-07T01:36:13Z |
| format | Journal article |
| id | oxford-uuid:9546048e-7101-4e51-b709-1526451585c9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:36:13Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:9546048e-7101-4e51-b709-1526451585c92022-03-26T23:45:09ZThe fecal metabolome as a functional readout of the gut microbiomeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9546048e-7101-4e51-b709-1526451585c9EnglishSymplectic Elements at OxfordNature Publishing Group2018Zierer, JJackson, MKastenmüller, GMangino, MLong, TTelenti, AMohney, RSmall, KBell, JSteves, CValdes, ASpector, TMenni, CThe human gut microbiome plays a key role in human health1, but 16S characterization lacks quantitative functional annotation2. The fecal metabolome provides a functional readout of microbial activity and can be used as an intermediate phenotype mediating host–microbiome interactions3. In this comprehensive description of the fecal metabolome, examining 1,116 metabolites from 786 individuals from a population-based twin study (TwinsUK), the fecal metabolome was found to be only modestly influenced by host genetics (heritability (H2) = 17.9%). One replicated locus at the NAT2 gene was associated with fecal metabolic traits. The fecal metabolome largely reflects gut microbial composition, explaining on average 67.7% (±18.8%) of its variance. It is strongly associated with visceral-fat mass, thereby illustrating potential mechanisms underlying the well-established microbial influence on abdominal obesity. Fecal metabolic profiling thus is a novel tool to explore links among microbiome composition, host phenotypes, and heritable complex traits. |
| spellingShingle | Zierer, J Jackson, M Kastenmüller, G Mangino, M Long, T Telenti, A Mohney, R Small, K Bell, J Steves, C Valdes, A Spector, T Menni, C The fecal metabolome as a functional readout of the gut microbiome |
| title | The fecal metabolome as a functional readout of the gut microbiome |
| title_full | The fecal metabolome as a functional readout of the gut microbiome |
| title_fullStr | The fecal metabolome as a functional readout of the gut microbiome |
| title_full_unstemmed | The fecal metabolome as a functional readout of the gut microbiome |
| title_short | The fecal metabolome as a functional readout of the gut microbiome |
| title_sort | fecal metabolome as a functional readout of the gut microbiome |
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