Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.
The semi-synthetic sulfated polysaccharide PPS (pentosan polysulfate) increases affinity between the aggrecan-degrading ADAMTSs (adamalysins with thrombospondin motifs) and their endogenous inhibitor, TIMP (tissue inhibitor of metalloproteinases)-3. In the present study we demonstrate that PPS media...
Main Authors: | Troeberg, L, Mulloy, B, Ghosh, P, Lee, M, Murphy, G, Nagase, H |
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Format: | Journal article |
Language: | English |
Published: |
2012
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