Chemical probes and inhibitors of bromodomains outside the BET family

Chemical probes and inhibitors of bromodomains outside the BET family

In the last five years, the development of inhibitors of bromodomains has emerged as an area of intensive worldwide research. Emerging evidence has implicated a number of non-BET bromodomains in the onset and progression of diseases such as cancer, HIV infection and inflammation. The development and...

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Bibliografiske detaljer
Main Authors:	Moustakim, M, Clark, P, Hay, D, Dixon, D, Brennan, P
Format:	Journal article
Udgivet:	Royal Society of Chemistry 2016

Lignende værker

Chemical probes for bromodomains outside the BET family
af: Brennan, P, et al.
Udgivet: (2013)

Development of a potent and selective bromodomain chemical probe
af: Moustakim, M, et al.
Udgivet: (2017)

Developing chemical probes for the BET bromodomains
af: Hewings, D, et al.
Udgivet: (2012)

Development of chemical probes for the bromodomains of BRD7 and BRD9
af: Clark, P, et al.
Udgivet: (2016)

The design and synthesis of 5-and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains
af: Hay, D, et al.
Udgivet: (2013)

Discovery of a PCAF bromodomain chemical probe
af: Moustakim, M, et al.
Udgivet: (2016)

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family.
af: Filippakopoulos, P, et al.
Udgivet: (2012)

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family
af: Filippakopoulos, P, et al.
Udgivet: (2012)

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.
af: Picaud, S, et al.
Udgivet: (2013)

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
af: Picaud, S, et al.
Udgivet: (2013)

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
af: Jennings, L, et al.
Udgivet: (2018)

Evaluation of linker length effects on a BET bromodomain probe
af: Traquete, R, et al.
Udgivet: (2019)

Synthesis and biological investigation of (+)-JD1, an organometallic BET bromodomain inhibitor
af: Hassell-Hart, S, et al.
Udgivet: (2019)

Selective inhibition of BET bromodomains.
af: Filippakopoulos, P, et al.
Udgivet: (2010)

Discovery of BET bromodomain inhibitors and their role in target validation
af: Mueller, S, et al.
Udgivet: (2014)

Selective inhibition of BET bromodomains.
af: Filippakopoulos, P, et al.
Udgivet: (2010)

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains.
af: Picaud, S, et al.
Udgivet: (2013)

Bioactivation of Isoxazole-Containing Bromodomain and Extra-Terminal Domain (BET) Inhibitors
af: Noah R. Flynn, et al.
Udgivet: (2021-06-01)

Discovery of epigenetic probes against the bromodomain family of proteins
af: Clark, P
Udgivet: (2015)

Design and synthesis of small molecule chemical probes for bromodomain-containing proteins.
af: Hay, D
Udgivet: (2014)

Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762
af: Chaidos, A, et al.
Udgivet: (2014)

BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
af: Kenneth K. W. To, et al.
Udgivet: (2023-03-01)

Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer
af: Shu, Shaokun, et al.
Udgivet: (2017)

Effect of BET missense mutations on bromodomain function, inhibitor binding and stability
af: Lori, L, et al.
Udgivet: (2016)

Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer
af: Alison M. Kurimchak, et al.
Udgivet: (2016-08-01)

Effect of BET Missense Mutations on Bromodomain Function, Inhibitor Binding and Stability.
af: Laura Lori, et al.
Udgivet: (2016-01-01)

BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer
af: Sergey Karakashev, et al.
Udgivet: (2017-12-01)

Bromodomain Inhibitors as Therapeutics for Herpesvirus-Related Disease: All BETs Are Off?
af: Ian J. Groves, et al.
Udgivet: (2020-07-01)

Design of a chemical probe for the bromodomain and plant homeodomain finger-containing (BRPF) family of proteins
af: Igoe, N, et al.
Udgivet: (2017)

Interactome rewiring following pharmacological targeting of BET bromodomains
af: Lambert, J-P, et al.
Udgivet: (2018)

BET bromodomain inhibitor HMBA synergizes with MEK inhibition in treatment of malignant glioma
af: Elisa Funck-Brentano, et al.
Udgivet: (2021-01-01)

Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers
af: Martin V. Nguyen, et al.
Udgivet: (2020-02-01)

BRD3 and BRD4 BET bromodomain proteins differentially regulate skeletal myogenesis
af: Roberts, T, et al.
Udgivet: (2017)

Selective BET bromodomain inhibition as an antifungal therapeutic strategy
af: Flore Mietton, et al.
Udgivet: (2017-05-01)

BET bromodomain proteins regulate enhancer function during adipogenesis
af: Brown, Jonathan D., et al.
Udgivet: (2018)

Anticancer Effects of I-BET151, an Inhibitor of Bromodomain and Extra-Terminal Domain Proteins
af: Jiacheng Lai, et al.
Udgivet: (2021-09-01)

Inhibition of BET Bromodomain Targets Genetically Diverse Glioblastoma
af: Cheng, Z, et al.
Udgivet: (2013)

Inhibition of BET bromodomain targets genetically diverse glioblastoma.
af: Cheng, Z, et al.
Udgivet: (2013)

Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition
af: Wendy Mao, et al.
Udgivet: (2019-10-01)

Bromodomain Blockade for Intimal Hyperplasia — A Good BET?
af: Allison C. Ostriker, et al.
Udgivet: (2015-11-01)