Quinine and severe falciparum malaria in late pregnancy.
Quinine dihydrochloride was given intravenously to 12 women with severe falciparum malaria in the third trimester of pregnancy. The initial dose consisted of 10 or 20 mg salt/kg over 4 h and was followed by 10 mg salt/kg every 8 h until patients were fit to swallow, when quinine sulphate tablets wer...
Main Authors: | , , , , , , , |
---|---|
Format: | Journal article |
Language: | English |
Published: |
1985
|
_version_ | 1797083086980120576 |
---|---|
author | Looareesuwan, S Phillips, R White, N Kietinun, S Karbwang, J Rackow, C Turner, R Warrell, D |
author_facet | Looareesuwan, S Phillips, R White, N Kietinun, S Karbwang, J Rackow, C Turner, R Warrell, D |
author_sort | Looareesuwan, S |
collection | OXFORD |
description | Quinine dihydrochloride was given intravenously to 12 women with severe falciparum malaria in the third trimester of pregnancy. The initial dose consisted of 10 or 20 mg salt/kg over 4 h and was followed by 10 mg salt/kg every 8 h until patients were fit to swallow, when quinine sulphate tablets were given. Uterine activity showed little or no change despite rising quinine concentrations. Of 3 patients in labour, 2 proceeded normally while a third had a successful caesarean section for fetal distress. Late (type II) decelerations of the fetal heart rate were recorded in 6 patients before treatment but in most patients signs of fetal distress diminished as the maternal temperature fell. Hypoglycaemia and hyperinsulinaemia developed in 7 patients, in 2 before quinine was started. The important toxic effect of quinine in late pregnancy is not an oxytocic action but rather its capacity to release insulin. |
first_indexed | 2024-03-07T01:37:00Z |
format | Journal article |
id | oxford-uuid:95890063-1087-40e3-a5ee-af3c703c1801 |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-07T01:37:00Z |
publishDate | 1985 |
record_format | dspace |
spelling | oxford-uuid:95890063-1087-40e3-a5ee-af3c703c18012022-03-26T23:46:48ZQuinine and severe falciparum malaria in late pregnancy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:95890063-1087-40e3-a5ee-af3c703c1801EnglishSymplectic Elements at Oxford1985Looareesuwan, SPhillips, RWhite, NKietinun, SKarbwang, JRackow, CTurner, RWarrell, DQuinine dihydrochloride was given intravenously to 12 women with severe falciparum malaria in the third trimester of pregnancy. The initial dose consisted of 10 or 20 mg salt/kg over 4 h and was followed by 10 mg salt/kg every 8 h until patients were fit to swallow, when quinine sulphate tablets were given. Uterine activity showed little or no change despite rising quinine concentrations. Of 3 patients in labour, 2 proceeded normally while a third had a successful caesarean section for fetal distress. Late (type II) decelerations of the fetal heart rate were recorded in 6 patients before treatment but in most patients signs of fetal distress diminished as the maternal temperature fell. Hypoglycaemia and hyperinsulinaemia developed in 7 patients, in 2 before quinine was started. The important toxic effect of quinine in late pregnancy is not an oxytocic action but rather its capacity to release insulin. |
spellingShingle | Looareesuwan, S Phillips, R White, N Kietinun, S Karbwang, J Rackow, C Turner, R Warrell, D Quinine and severe falciparum malaria in late pregnancy. |
title | Quinine and severe falciparum malaria in late pregnancy. |
title_full | Quinine and severe falciparum malaria in late pregnancy. |
title_fullStr | Quinine and severe falciparum malaria in late pregnancy. |
title_full_unstemmed | Quinine and severe falciparum malaria in late pregnancy. |
title_short | Quinine and severe falciparum malaria in late pregnancy. |
title_sort | quinine and severe falciparum malaria in late pregnancy |
work_keys_str_mv | AT looareesuwans quinineandseverefalciparummalariainlatepregnancy AT phillipsr quinineandseverefalciparummalariainlatepregnancy AT whiten quinineandseverefalciparummalariainlatepregnancy AT kietinuns quinineandseverefalciparummalariainlatepregnancy AT karbwangj quinineandseverefalciparummalariainlatepregnancy AT rackowc quinineandseverefalciparummalariainlatepregnancy AT turnerr quinineandseverefalciparummalariainlatepregnancy AT warrelld quinineandseverefalciparummalariainlatepregnancy |