Isocitrate dehydrogenase gene variants in cancer and their clinical significance
Human isocitrate dehydrogenase (IDH) genes encode for the IDH1, 2 & 3 isoenzymes which catalyse the formation of 2-oxoglutarate from isocitrate and are essential for normal mammalian metabolism. Although mutations in these genes in cancer were long thought to lead to a ‘loss of function’, combin...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Portland Press
2021
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