Leukemia-related transcription factor TEL/ETV6 expands erythroid precursors and stimulates hemoglobin synthesis.
TEL/ETV6 located at chromosome 12p13 encodes a member of the E26 transformation-specific family of transcription factors. TEL is known to be rearranged in a variety of leukemias and solid tumors resulting in the formation of oncogenic chimeric protein. Tel is essential for maintaining hematopoietic...
Autori principali: | Eguchi-Ishimae, M, Eguchi, M, Maki, K, Porcher, C, Shimizu, R, Yamamoto, M, Mitani, K |
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Natura: | Journal article |
Lingua: | English |
Pubblicazione: |
2009
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