Antibodies for inflammatory disease : cytokines.
Cytokines are small proteins and major mediators of local intercellular communication required for an integrated response to a variety of stimuli in immune and inflammatory responses. By binding their cognate receptors on target cells, these short-lived molecules play a role in many important biolog...
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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2000
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| _version_ | 1797083157921529856 |
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| author | Taylor, P |
| author_facet | Taylor, P |
| author_sort | Taylor, P |
| collection | OXFORD |
| description | Cytokines are small proteins and major mediators of local intercellular communication required for an integrated response to a variety of stimuli in immune and inflammatory responses. By binding their cognate receptors on target cells, these short-lived molecules play a role in many important biological processes, including cell proliferation, activation, death, and differentiation. During an inflammatory response many cytokines are synthesized by a wide range of cell types, including leukocytes and fibroblasts. Some cytokines are proinflammatory, such as interleukin-1 (IL-1) and tumor necrosis factor a (TNF-α); others, such as interleukin-10 (IL-10) and transforming growth factor β(TGF-β), exert predominantly anti-inflammatory effects. However, it is now understood that many cytokines, for example, interferon-γ (IFN-γ), with chiefly proinflammatory activity, can also in some instances have anti-inflammatory properties. Similarly, cytokines with predominantly anti-inflammatory activity, such as IL-10 and TGF-β may also exhibit proinflammatory properties and therefore have pathogenic potential. Paracrine or autocrine pathways involving cytokines with either pro- or anti-inflammatory activity can lead to reverberating networks determining whether chronic inflammation results. |
| first_indexed | 2024-03-07T01:37:50Z |
| format | Journal article |
| id | oxford-uuid:95d144d3-8b8b-49eb-a7e2-23aa0637661e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:37:50Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:95d144d3-8b8b-49eb-a7e2-23aa0637661e2022-03-26T23:48:40ZAntibodies for inflammatory disease : cytokines.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:95d144d3-8b8b-49eb-a7e2-23aa0637661eEnglishSymplectic Elements at Oxford2000Taylor, PCytokines are small proteins and major mediators of local intercellular communication required for an integrated response to a variety of stimuli in immune and inflammatory responses. By binding their cognate receptors on target cells, these short-lived molecules play a role in many important biological processes, including cell proliferation, activation, death, and differentiation. During an inflammatory response many cytokines are synthesized by a wide range of cell types, including leukocytes and fibroblasts. Some cytokines are proinflammatory, such as interleukin-1 (IL-1) and tumor necrosis factor a (TNF-α); others, such as interleukin-10 (IL-10) and transforming growth factor β(TGF-β), exert predominantly anti-inflammatory effects. However, it is now understood that many cytokines, for example, interferon-γ (IFN-γ), with chiefly proinflammatory activity, can also in some instances have anti-inflammatory properties. Similarly, cytokines with predominantly anti-inflammatory activity, such as IL-10 and TGF-β may also exhibit proinflammatory properties and therefore have pathogenic potential. Paracrine or autocrine pathways involving cytokines with either pro- or anti-inflammatory activity can lead to reverberating networks determining whether chronic inflammation results. |
| spellingShingle | Taylor, P Antibodies for inflammatory disease : cytokines. |
| title | Antibodies for inflammatory disease : cytokines. |
| title_full | Antibodies for inflammatory disease : cytokines. |
| title_fullStr | Antibodies for inflammatory disease : cytokines. |
| title_full_unstemmed | Antibodies for inflammatory disease : cytokines. |
| title_short | Antibodies for inflammatory disease : cytokines. |
| title_sort | antibodies for inflammatory disease cytokines |
| work_keys_str_mv | AT taylorp antibodiesforinflammatorydiseasecytokines |