Association of depression and anxiety with cognitive impairment 6 months after stroke
<p><strong>OBJECTIVE:</strong> Investigate the associations between general cognitive impairment and domain specific cognitive impairment with post-stroke depression and anxiety at six-months post-stroke.</p> <p><strong>METHODS:</strong> Participants were c...
| Main Authors: | , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
American Academy of Neurology
2021
|
| _version_ | 1797083223133519872 |
|---|---|
| author | Williams, OA Demeyere, N |
| author_facet | Williams, OA Demeyere, N |
| author_sort | Williams, OA |
| collection | OXFORD |
| description | <p><strong>OBJECTIVE:</strong> Investigate the associations between general cognitive impairment and domain specific cognitive impairment with post-stroke depression and anxiety at six-months post-stroke.</p>
<p><strong>METHODS:</strong> Participants were confirmed acute stroke patients from the OCS-CARE study who were recruited on stroke wards in a multi-site study and followed up at a 6 months post-stroke assessment. Depression and anxiety symptoms were assessed by the Hospital Anxiety and Depression Scale sub-scales, with scores greater than seven indicating possible mood disorders. General cognitive impairment at follow-up was assessed using the Montreal Cognitive Assessment, stroke-specific cognitive domain impairments was assessed using the Oxford Cognitive Screen. Linear regression was used to examine the associations between cognition and depression/anxiety symptoms at 6-months, controlling for acute-stroke severity and ADL-impairment, age, sex, education, and co-occurring post-stroke depression/anxiety.</p>
<p><strong>RESULTS:</strong> 437 participants mean age=69.28 years (S.D.=12.17), 226 male (51.72%), were included in analyses. Six-month post-stroke depression (n=115, 26%) was associated with six-month impairment on the MoCA (beta [b] =0.96, standard error [SE] =0.31, p=0.006), and all individual domains assessed by the OCS: spatial attention (b=0.67, SE=0.33, p =0.041), executive function (b=1.37, SE=0.47, p=0.004), language processing (b=0.87, SE=0.38, p=0.028), memory (b=0.76, SE=0.37, p=0.040), number processing (b=1.13, SE=0.40, p=0.005), praxis (b=1.16, SE =0.49, p=0.028). Post-stroke anxiety (n=133, 30%) was associated with impairment on the MoCA (b=1.47, SE=0.42, p=0.001), and spatial attention (b=1.25, SE=0.45, p=0.006), these associations did not remain significant after controlling for co-occurring post-stroke depression.</p>
<p><strong>CONCLUSION:</strong> Domain-general and domain-specific post-stroke cognitive impairment was found to be highly related to depressive symptomatology but not anxiety symptomatology.</p> |
| first_indexed | 2024-03-07T01:38:40Z |
| format | Journal article |
| id | oxford-uuid:96158dbb-20cb-43ad-91f2-3f1850e2e89e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:38:40Z |
| publishDate | 2021 |
| publisher | American Academy of Neurology |
| record_format | dspace |
| spelling | oxford-uuid:96158dbb-20cb-43ad-91f2-3f1850e2e89e2022-03-26T23:50:36ZAssociation of depression and anxiety with cognitive impairment 6 months after strokeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:96158dbb-20cb-43ad-91f2-3f1850e2e89eEnglishSymplectic ElementsAmerican Academy of Neurology2021Williams, OADemeyere, N<p><strong>OBJECTIVE:</strong> Investigate the associations between general cognitive impairment and domain specific cognitive impairment with post-stroke depression and anxiety at six-months post-stroke.</p> <p><strong>METHODS:</strong> Participants were confirmed acute stroke patients from the OCS-CARE study who were recruited on stroke wards in a multi-site study and followed up at a 6 months post-stroke assessment. Depression and anxiety symptoms were assessed by the Hospital Anxiety and Depression Scale sub-scales, with scores greater than seven indicating possible mood disorders. General cognitive impairment at follow-up was assessed using the Montreal Cognitive Assessment, stroke-specific cognitive domain impairments was assessed using the Oxford Cognitive Screen. Linear regression was used to examine the associations between cognition and depression/anxiety symptoms at 6-months, controlling for acute-stroke severity and ADL-impairment, age, sex, education, and co-occurring post-stroke depression/anxiety.</p> <p><strong>RESULTS:</strong> 437 participants mean age=69.28 years (S.D.=12.17), 226 male (51.72%), were included in analyses. Six-month post-stroke depression (n=115, 26%) was associated with six-month impairment on the MoCA (beta [b] =0.96, standard error [SE] =0.31, p=0.006), and all individual domains assessed by the OCS: spatial attention (b=0.67, SE=0.33, p =0.041), executive function (b=1.37, SE=0.47, p=0.004), language processing (b=0.87, SE=0.38, p=0.028), memory (b=0.76, SE=0.37, p=0.040), number processing (b=1.13, SE=0.40, p=0.005), praxis (b=1.16, SE =0.49, p=0.028). Post-stroke anxiety (n=133, 30%) was associated with impairment on the MoCA (b=1.47, SE=0.42, p=0.001), and spatial attention (b=1.25, SE=0.45, p=0.006), these associations did not remain significant after controlling for co-occurring post-stroke depression.</p> <p><strong>CONCLUSION:</strong> Domain-general and domain-specific post-stroke cognitive impairment was found to be highly related to depressive symptomatology but not anxiety symptomatology.</p> |
| spellingShingle | Williams, OA Demeyere, N Association of depression and anxiety with cognitive impairment 6 months after stroke |
| title | Association of depression and anxiety with cognitive impairment 6 months after stroke |
| title_full | Association of depression and anxiety with cognitive impairment 6 months after stroke |
| title_fullStr | Association of depression and anxiety with cognitive impairment 6 months after stroke |
| title_full_unstemmed | Association of depression and anxiety with cognitive impairment 6 months after stroke |
| title_short | Association of depression and anxiety with cognitive impairment 6 months after stroke |
| title_sort | association of depression and anxiety with cognitive impairment 6 months after stroke |
| work_keys_str_mv | AT williamsoa associationofdepressionandanxietywithcognitiveimpairment6monthsafterstroke AT demeyeren associationofdepressionandanxietywithcognitiveimpairment6monthsafterstroke |