The association between blood test trends and undiagnosed cancer: a systematic review and critical appraisal
Clinical guidelines include monitoring blood test abnormalities to identify patients at increased risk of undiagnosed cancer. Noting blood test changes over time may improve cancer risk stratification by considering a patient’s individual baseline and important changes within the normal range. We ai...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2024
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| _version_ | 1811139735227203584 |
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| author | Virdee, PS Collins, KK Friedemann Smith, C Yang, X Zhu, S Roberts, SE Roberts, N Oke, JL Bankhead, C Perera, R Hobbs, FDR Nicholson, BD |
| author_facet | Virdee, PS Collins, KK Friedemann Smith, C Yang, X Zhu, S Roberts, SE Roberts, N Oke, JL Bankhead, C Perera, R Hobbs, FDR Nicholson, BD |
| author_sort | Virdee, PS |
| collection | OXFORD |
| description | Clinical guidelines include monitoring blood test abnormalities to identify patients at increased risk of undiagnosed cancer. Noting blood test changes over time may improve cancer risk stratification by considering a patient’s individual baseline and important changes within the normal range. We aimed to review the published literature to understand the association between blood test trends and undiagnosed cancer. MEDLINE and EMBASE were searched until 15 May 2023 for studies assessing the association between blood test trends and undiagnosed cancer. We used descriptive summaries and narratively synthesised studies. We included 29 articles. Common blood tests were haemoglobin (24%, n = 7), C-reactive protein (17%, n = 5), and fasting blood glucose (17%, n = 5), and common cancers were pancreatic (29%, n = 8) and colorectal (17%, n = 5). Of the 30 blood tests studied, an increasing trend in eight (27%) was associated with eight cancer types, and a decreasing trend in 17 (57%) with 10 cancer types. No association was reported between trends in 11 (37%) tests and breast, bile duct, glioma, haematological combined, liver, prostate, or thyroid cancers. Our review highlights trends in blood tests that could facilitate the identification of individuals at increased risk of undiagnosed cancer. For most possible combinations of tests and cancers, there was limited or no evidence. |
| first_indexed | 2024-09-25T04:10:48Z |
| format | Journal article |
| id | oxford-uuid:9628326d-c988-4fc7-b044-8b2014ed1e6d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:10:48Z |
| publishDate | 2024 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:9628326d-c988-4fc7-b044-8b2014ed1e6d2024-06-18T13:27:41ZThe association between blood test trends and undiagnosed cancer: a systematic review and critical appraisalJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9628326d-c988-4fc7-b044-8b2014ed1e6dEnglishSymplectic ElementsMDPI2024Virdee, PSCollins, KKFriedemann Smith, CYang, XZhu, SRoberts, SERoberts, NOke, JLBankhead, CPerera, RHobbs, FDRNicholson, BDClinical guidelines include monitoring blood test abnormalities to identify patients at increased risk of undiagnosed cancer. Noting blood test changes over time may improve cancer risk stratification by considering a patient’s individual baseline and important changes within the normal range. We aimed to review the published literature to understand the association between blood test trends and undiagnosed cancer. MEDLINE and EMBASE were searched until 15 May 2023 for studies assessing the association between blood test trends and undiagnosed cancer. We used descriptive summaries and narratively synthesised studies. We included 29 articles. Common blood tests were haemoglobin (24%, n = 7), C-reactive protein (17%, n = 5), and fasting blood glucose (17%, n = 5), and common cancers were pancreatic (29%, n = 8) and colorectal (17%, n = 5). Of the 30 blood tests studied, an increasing trend in eight (27%) was associated with eight cancer types, and a decreasing trend in 17 (57%) with 10 cancer types. No association was reported between trends in 11 (37%) tests and breast, bile duct, glioma, haematological combined, liver, prostate, or thyroid cancers. Our review highlights trends in blood tests that could facilitate the identification of individuals at increased risk of undiagnosed cancer. For most possible combinations of tests and cancers, there was limited or no evidence. |
| spellingShingle | Virdee, PS Collins, KK Friedemann Smith, C Yang, X Zhu, S Roberts, SE Roberts, N Oke, JL Bankhead, C Perera, R Hobbs, FDR Nicholson, BD The association between blood test trends and undiagnosed cancer: a systematic review and critical appraisal |
| title | The association between blood test trends and undiagnosed cancer: a systematic review and critical appraisal |
| title_full | The association between blood test trends and undiagnosed cancer: a systematic review and critical appraisal |
| title_fullStr | The association between blood test trends and undiagnosed cancer: a systematic review and critical appraisal |
| title_full_unstemmed | The association between blood test trends and undiagnosed cancer: a systematic review and critical appraisal |
| title_short | The association between blood test trends and undiagnosed cancer: a systematic review and critical appraisal |
| title_sort | association between blood test trends and undiagnosed cancer a systematic review and critical appraisal |
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