A comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand.
Thai adult males (N = 85) with acute Plasmodium vivax malaria and normal glucose-6-phosphate dehydrogenase screening were randomized to receive 30 mg or 60 mg primaquine daily for 7 days (N = 43 and 42, respectively). The regimens were well tolerated and all patients recovered fully. Median fever cl...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
2010
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| _version_ | 1826286119329726464 |
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| author | Pukrittayakamee, S Imwong, M Chotivanich, K Singhasivanon, P Day, N White, N |
| author_facet | Pukrittayakamee, S Imwong, M Chotivanich, K Singhasivanon, P Day, N White, N |
| author_sort | Pukrittayakamee, S |
| collection | OXFORD |
| description | Thai adult males (N = 85) with acute Plasmodium vivax malaria and normal glucose-6-phosphate dehydrogenase screening were randomized to receive 30 mg or 60 mg primaquine daily for 7 days (N = 43 and 42, respectively). The regimens were well tolerated and all patients recovered fully. Median fever clearance (47 hours; range 4 to 130 hours), mean + or - SD parasite clearance times (87.7 + or - 25.3 hours), gametocyte clearance, and adverse effects were similar in the 2 groups. Two patients, 1 from each group, had a 30% reduction in hematocrit. The cumulative 28 day relapse rate (95% confidence interval) by Kaplan Meier survival analysis was 29% (16-49%) in the 30 mg group compared with 7% (2-24%) in the 60 mg group; P = 0.027. Comparison with previous data obtained at this same site suggests that the recurrences comprised approximately 17% recrudescences and 12% relapses in the 30 mg/day group compared with 3% recrudescences and 4% relapses in the 60 mg/day group. These data suggest that the dose-response relationships for primaquine's asexual stage and hypnozoitocidal activities in-vivo are different. A 1 week course of primaquine 60 mg daily is an effective treatment of vivax malaria in this region. |
| first_indexed | 2024-03-07T01:39:02Z |
| format | Journal article |
| id | oxford-uuid:963162e7-f947-435b-8c08-656feba27db9 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:39:02Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:963162e7-f947-435b-8c08-656feba27db92022-03-26T23:51:27ZA comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:963162e7-f947-435b-8c08-656feba27db9EnglishSymplectic Elements at Oxford2010Pukrittayakamee, SImwong, MChotivanich, KSinghasivanon, PDay, NWhite, NThai adult males (N = 85) with acute Plasmodium vivax malaria and normal glucose-6-phosphate dehydrogenase screening were randomized to receive 30 mg or 60 mg primaquine daily for 7 days (N = 43 and 42, respectively). The regimens were well tolerated and all patients recovered fully. Median fever clearance (47 hours; range 4 to 130 hours), mean + or - SD parasite clearance times (87.7 + or - 25.3 hours), gametocyte clearance, and adverse effects were similar in the 2 groups. Two patients, 1 from each group, had a 30% reduction in hematocrit. The cumulative 28 day relapse rate (95% confidence interval) by Kaplan Meier survival analysis was 29% (16-49%) in the 30 mg group compared with 7% (2-24%) in the 60 mg group; P = 0.027. Comparison with previous data obtained at this same site suggests that the recurrences comprised approximately 17% recrudescences and 12% relapses in the 30 mg/day group compared with 3% recrudescences and 4% relapses in the 60 mg/day group. These data suggest that the dose-response relationships for primaquine's asexual stage and hypnozoitocidal activities in-vivo are different. A 1 week course of primaquine 60 mg daily is an effective treatment of vivax malaria in this region. |
| spellingShingle | Pukrittayakamee, S Imwong, M Chotivanich, K Singhasivanon, P Day, N White, N A comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand. |
| title | A comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand. |
| title_full | A comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand. |
| title_fullStr | A comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand. |
| title_full_unstemmed | A comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand. |
| title_short | A comparison of two short-course primaquine regimens for the treatment and radical cure of Plasmodium vivax malaria in Thailand. |
| title_sort | comparison of two short course primaquine regimens for the treatment and radical cure of plasmodium vivax malaria in thailand |
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