Haptoglobin genotype, anaemia and malaria in Gambian children.
OBJECTIVE: To retest our previous finding that the haptoglobin (Hp) 22 genotype is associated with seasonal anaemia, and to investigate the role of malaria in this effect. METHODS: Haemoglobin (Hb) and peripheral parasitaemia were assessed at pre- and post-malarial season cross-sectional surveys in...
| المؤلفون الرئيسيون: | , , , , , , , , |
|---|---|
| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
2008
|
| _version_ | 1826286120762081280 |
|---|---|
| author | Cox, SE Doherty, C Atkinson, S Nweneka, C Fulford, A Sirugo, G Rockett, K Kwiatkowski, D Prentice, A |
| author_facet | Cox, SE Doherty, C Atkinson, S Nweneka, C Fulford, A Sirugo, G Rockett, K Kwiatkowski, D Prentice, A |
| author_sort | Cox, SE |
| collection | OXFORD |
| description | OBJECTIVE: To retest our previous finding that the haptoglobin (Hp) 22 genotype is associated with seasonal anaemia, and to investigate the role of malaria in this effect. METHODS: Haemoglobin (Hb) and peripheral parasitaemia were assessed at pre- and post-malarial season cross-sectional surveys in rural Gambian children aged 10-72 months. Between the surveys, active longitudinal surveillance was conducted to detect febrile episodes. RESULTS: Unlike previously, no overall reduction in Hb was observed (Hb = 106.1 vs. 107.2 g/l, P = 0.13, n = 545). However, multi-variable linear regression revealed differences in Hb over the season by Hp and Hb-sickle (HbS) genotype (-2.20 g/l per copy of the Hp2 allele, P = 0.043; HbAS vs. HbAA + 3.13 g/l, P = 0.11, n = 536). There was no effect of malarial episodes during follow-up; this suggests that when effective treatment is given, Hb levels recover. The A61-C Hp promoter SNP, associated with the Hp2 allele, had no effect. CONCLUSION: The effect of the Hp2 allele appears to be independent of effects on malaria incidence but may affect Hb levels through increased oxidant stress and red cell turnover. This may be supported by our previous observations that the effect of Hp22 was independent of markers of iron status and zinc protoporphyrin measured at the cross-sectional surveys and therefore also of iron availability for erythropoiesis. |
| first_indexed | 2024-03-07T01:39:03Z |
| format | Journal article |
| id | oxford-uuid:96336f2d-7be9-4138-8194-e4e8e26b2f4e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:39:03Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:96336f2d-7be9-4138-8194-e4e8e26b2f4e2022-03-26T23:51:27ZHaptoglobin genotype, anaemia and malaria in Gambian children.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:96336f2d-7be9-4138-8194-e4e8e26b2f4eEnglishSymplectic Elements at Oxford2008Cox, SEDoherty, CAtkinson, SNweneka, CFulford, ASirugo, GRockett, KKwiatkowski, DPrentice, AOBJECTIVE: To retest our previous finding that the haptoglobin (Hp) 22 genotype is associated with seasonal anaemia, and to investigate the role of malaria in this effect. METHODS: Haemoglobin (Hb) and peripheral parasitaemia were assessed at pre- and post-malarial season cross-sectional surveys in rural Gambian children aged 10-72 months. Between the surveys, active longitudinal surveillance was conducted to detect febrile episodes. RESULTS: Unlike previously, no overall reduction in Hb was observed (Hb = 106.1 vs. 107.2 g/l, P = 0.13, n = 545). However, multi-variable linear regression revealed differences in Hb over the season by Hp and Hb-sickle (HbS) genotype (-2.20 g/l per copy of the Hp2 allele, P = 0.043; HbAS vs. HbAA + 3.13 g/l, P = 0.11, n = 536). There was no effect of malarial episodes during follow-up; this suggests that when effective treatment is given, Hb levels recover. The A61-C Hp promoter SNP, associated with the Hp2 allele, had no effect. CONCLUSION: The effect of the Hp2 allele appears to be independent of effects on malaria incidence but may affect Hb levels through increased oxidant stress and red cell turnover. This may be supported by our previous observations that the effect of Hp22 was independent of markers of iron status and zinc protoporphyrin measured at the cross-sectional surveys and therefore also of iron availability for erythropoiesis. |
| spellingShingle | Cox, SE Doherty, C Atkinson, S Nweneka, C Fulford, A Sirugo, G Rockett, K Kwiatkowski, D Prentice, A Haptoglobin genotype, anaemia and malaria in Gambian children. |
| title | Haptoglobin genotype, anaemia and malaria in Gambian children. |
| title_full | Haptoglobin genotype, anaemia and malaria in Gambian children. |
| title_fullStr | Haptoglobin genotype, anaemia and malaria in Gambian children. |
| title_full_unstemmed | Haptoglobin genotype, anaemia and malaria in Gambian children. |
| title_short | Haptoglobin genotype, anaemia and malaria in Gambian children. |
| title_sort | haptoglobin genotype anaemia and malaria in gambian children |
| work_keys_str_mv | AT coxse haptoglobingenotypeanaemiaandmalariaingambianchildren AT dohertyc haptoglobingenotypeanaemiaandmalariaingambianchildren AT atkinsons haptoglobingenotypeanaemiaandmalariaingambianchildren AT nwenekac haptoglobingenotypeanaemiaandmalariaingambianchildren AT fulforda haptoglobingenotypeanaemiaandmalariaingambianchildren AT sirugog haptoglobingenotypeanaemiaandmalariaingambianchildren AT rockettk haptoglobingenotypeanaemiaandmalariaingambianchildren AT kwiatkowskid haptoglobingenotypeanaemiaandmalariaingambianchildren AT prenticea haptoglobingenotypeanaemiaandmalariaingambianchildren |