Modelling Spatially Regulated beta−Catenin Dynamics and Invasion in Intestinal Crypts

Experimental data (e.g., genetic lineage and cell population studies) on intestinal crypts reveal that regulatory features of crypt behavior, such as control via morphogen gradients, are remarkably well conserved among numerous organisms (e.g., from mouse and rat to human) and throughout the differe...

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Bibliographic Details
Main Authors: Murray, P, Kang, J, Mirams, G, Shin, S, Byrne, H, Maini, P, Cho, K
Format: Journal article
Published: 2010
Description
Summary:Experimental data (e.g., genetic lineage and cell population studies) on intestinal crypts reveal that regulatory features of crypt behavior, such as control via morphogen gradients, are remarkably well conserved among numerous organisms (e.g., from mouse and rat to human) and throughout the different regions of the small and large intestines. In this article, we construct a partial differential equation model of a single colonic crypt that