1,4-Dideoxy-1,4-imino-D-mannitol inhibits glycoprotein processing and mannosidase.

1,4-Dideoxy-1,4-imino-D-mannitol (DIM) was synthesized chemically from benzyl-alpha-D-mannopyranoside [Fleet et al (1984) J. Chem. Soc. Chem. Commun., 1240-1241], and was tested in vitro as an inhibitor of various alpha-mannosidases and in cell culture as an inhibitor of glycoprotein processing. DIM...

詳細記述

書誌詳細
主要な著者: Palamarczyk, G, Mitchell, M, Smith, P, Fleet, G, Elbein, A
フォーマット: Journal article
言語:English
出版事項: 1985