Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation
Most mammalian protein coding genes are subject to alternative cleavage and polyadenylation (APA), which can generate distinct mRNA 3'UTRs with differing regulatory potential. Although this process has been intensely studied in recent years, it remains unclear how and to what extent cleavage si...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Portland Press
2016
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| _version_ | 1797083264164298752 |
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| author | Hardy, J Norbury, C |
| author_facet | Hardy, J Norbury, C |
| author_sort | Hardy, J |
| collection | OXFORD |
| description | Most mammalian protein coding genes are subject to alternative cleavage and polyadenylation (APA), which can generate distinct mRNA 3'UTRs with differing regulatory potential. Although this process has been intensely studied in recent years, it remains unclear how and to what extent cleavage site selection is regulated under different physiological conditions. The cleavage factor Im (CFIm) complex is a core component of the mammalian cleavage machinery, and the observation that its depletion causes transcriptome-wide changes in cleavage site use makes it a key candidate regulator of APA. This review aims to summarize current knowledge of the CFIm complex, and explores the evidence surrounding its potential contribution to regulation of APA. |
| first_indexed | 2024-03-07T01:39:16Z |
| format | Journal article |
| id | oxford-uuid:964ad012-7b51-4a2a-b283-2a8d5f9002c3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:39:16Z |
| publishDate | 2016 |
| publisher | Portland Press |
| record_format | dspace |
| spelling | oxford-uuid:964ad012-7b51-4a2a-b283-2a8d5f9002c32022-03-26T23:51:59ZCleavage factor Im (CFIm) as a regulator of alternative polyadenylationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:964ad012-7b51-4a2a-b283-2a8d5f9002c3EnglishSymplectic Elements at OxfordPortland Press2016Hardy, JNorbury, CMost mammalian protein coding genes are subject to alternative cleavage and polyadenylation (APA), which can generate distinct mRNA 3'UTRs with differing regulatory potential. Although this process has been intensely studied in recent years, it remains unclear how and to what extent cleavage site selection is regulated under different physiological conditions. The cleavage factor Im (CFIm) complex is a core component of the mammalian cleavage machinery, and the observation that its depletion causes transcriptome-wide changes in cleavage site use makes it a key candidate regulator of APA. This review aims to summarize current knowledge of the CFIm complex, and explores the evidence surrounding its potential contribution to regulation of APA. |
| spellingShingle | Hardy, J Norbury, C Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation |
| title | Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation |
| title_full | Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation |
| title_fullStr | Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation |
| title_full_unstemmed | Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation |
| title_short | Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation |
| title_sort | cleavage factor im cfim as a regulator of alternative polyadenylation |
| work_keys_str_mv | AT hardyj cleavagefactorimcfimasaregulatorofalternativepolyadenylation AT norburyc cleavagefactorimcfimasaregulatorofalternativepolyadenylation |