Dual action ectoparasite vaccine targeting 'exposed' and 'concealed' antigens.
Blood-feeding ectoparasites, such as mosquitoes, sandflies and ticks, transmit many disease agents. Their control relies on large-scale, repeated use of chemical pesticides. An alternative, targeted and environmentally friendly approach is to develop anti-ectoparasite vaccines. We describe a vaccine...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2002
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| _version_ | 1826286138453655552 |
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| author | Trimnell, A Hails, R Nuttall, P |
| author_facet | Trimnell, A Hails, R Nuttall, P |
| author_sort | Trimnell, A |
| collection | OXFORD |
| description | Blood-feeding ectoparasites, such as mosquitoes, sandflies and ticks, transmit many disease agents. Their control relies on large-scale, repeated use of chemical pesticides. An alternative, targeted and environmentally friendly approach is to develop anti-ectoparasite vaccines. We describe a vaccine to control ticks that targets an 'exposed' tick saliva antigen and cross-reacts with 'concealed' tick midgut antigens. Ticks feeding on immunised animals induced a cutaneous inflammatory response and increased antibody titer, while engorged ticks died following damage to their midgut. This dual action, acting at the feeding site and in the midgut, offers a self-sustaining strategy for ectoparasite control boosted by natural infestations. |
| first_indexed | 2024-03-07T01:39:19Z |
| format | Journal article |
| id | oxford-uuid:96509fa4-f615-43af-a8f4-f01573f34152 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:39:19Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:96509fa4-f615-43af-a8f4-f01573f341522022-03-26T23:52:01ZDual action ectoparasite vaccine targeting 'exposed' and 'concealed' antigens.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:96509fa4-f615-43af-a8f4-f01573f34152EnglishSymplectic Elements at Oxford2002Trimnell, AHails, RNuttall, PBlood-feeding ectoparasites, such as mosquitoes, sandflies and ticks, transmit many disease agents. Their control relies on large-scale, repeated use of chemical pesticides. An alternative, targeted and environmentally friendly approach is to develop anti-ectoparasite vaccines. We describe a vaccine to control ticks that targets an 'exposed' tick saliva antigen and cross-reacts with 'concealed' tick midgut antigens. Ticks feeding on immunised animals induced a cutaneous inflammatory response and increased antibody titer, while engorged ticks died following damage to their midgut. This dual action, acting at the feeding site and in the midgut, offers a self-sustaining strategy for ectoparasite control boosted by natural infestations. |
| spellingShingle | Trimnell, A Hails, R Nuttall, P Dual action ectoparasite vaccine targeting 'exposed' and 'concealed' antigens. |
| title | Dual action ectoparasite vaccine targeting 'exposed' and 'concealed' antigens. |
| title_full | Dual action ectoparasite vaccine targeting 'exposed' and 'concealed' antigens. |
| title_fullStr | Dual action ectoparasite vaccine targeting 'exposed' and 'concealed' antigens. |
| title_full_unstemmed | Dual action ectoparasite vaccine targeting 'exposed' and 'concealed' antigens. |
| title_short | Dual action ectoparasite vaccine targeting 'exposed' and 'concealed' antigens. |
| title_sort | dual action ectoparasite vaccine targeting exposed and concealed antigens |
| work_keys_str_mv | AT trimnella dualactionectoparasitevaccinetargetingexposedandconcealedantigens AT hailsr dualactionectoparasitevaccinetargetingexposedandconcealedantigens AT nuttallp dualactionectoparasitevaccinetargetingexposedandconcealedantigens |