Interplay of cascade oxidative cyclization and hydride shifts in the synthesis of the ABC spiroketal ring system of pectenotoxin-4.
Concepts: The formation of stereochemically defined bis-THF units through a double cyclization and a hydride-shift-initiated route to spiroketals is described (see scheme; Xc=chiral auxiliary). The resulting sequence has been used in a synthesis of the C1-16 fragment of the naturally occurring antit...
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Bibliographic Details
| Main Authors: |
Donohoe, T,
Lipiński, R |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2013
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