Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment

Introduction: Unwanted drug interactions with ionic currents in the heart can lead to an increased pro-arrhythmic risk to patients in the clinic. It is therefore a priority for safety pharmacology teams to detect block of cardiac ion channels, and new technologies have enabled the development of aut...

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Xehetasun bibliografikoak
Egile Nagusiak: Elkins, R, Davies, MR, Brough, S, Gavaghan, D, Cui, Y, Abi-Gerges, N, Mirams, G
Formatua: Journal article
Hizkuntza:English
Argitaratua: 2013