Autophagy is a critical regulator of memory CD8(+) T cell formation.
During infection, CD8(+) T cells initially expand then contract, leaving a small memory pool providing long lasting immunity. While it has been described that CD8(+) T cell memory formation becomes defective in old age, the cellular mechanism is largely unknown. Autophagy is a major cellular lysosom...
| Asıl Yazarlar: | , , , , , , , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
eLife Sciences Publications
2014
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| _version_ | 1826286185163522048 |
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| author | Puleston, D Zhang, H Powell, T Lipina, E Sims, S Panse, I Watson, A Cerundolo, V Townsend, A Klenerman, P Simon, A |
| author_facet | Puleston, D Zhang, H Powell, T Lipina, E Sims, S Panse, I Watson, A Cerundolo, V Townsend, A Klenerman, P Simon, A |
| author_sort | Puleston, D |
| collection | OXFORD |
| description | During infection, CD8(+) T cells initially expand then contract, leaving a small memory pool providing long lasting immunity. While it has been described that CD8(+) T cell memory formation becomes defective in old age, the cellular mechanism is largely unknown. Autophagy is a major cellular lysosomal degradation pathway of bulk material, and levels are known to fall with age. In this study, we describe a novel role for autophagy in CD8(+) T cell memory formation. Mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection. Interestingly, autophagy levels were diminished in CD8(+) T cells from aged mice. We could rejuvenate CD8(+) T cell responses in elderly mice in an autophagy dependent manner using the compound spermidine. This study reveals a cell intrinsic explanation for poor CD8(+) T cell memory in the elderly and potentially offers novel immune modulators to improve aged immunity. |
| first_indexed | 2024-03-07T01:40:03Z |
| format | Journal article |
| id | oxford-uuid:9689d241-9dce-4145-9af9-2189afa1a577 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:40:03Z |
| publishDate | 2014 |
| publisher | eLife Sciences Publications |
| record_format | dspace |
| spelling | oxford-uuid:9689d241-9dce-4145-9af9-2189afa1a5772022-03-26T23:53:38ZAutophagy is a critical regulator of memory CD8(+) T cell formation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9689d241-9dce-4145-9af9-2189afa1a577EnglishSymplectic Elements at OxfordeLife Sciences Publications2014Puleston, DZhang, HPowell, TLipina, ESims, SPanse, IWatson, ACerundolo, VTownsend, AKlenerman, PSimon, ADuring infection, CD8(+) T cells initially expand then contract, leaving a small memory pool providing long lasting immunity. While it has been described that CD8(+) T cell memory formation becomes defective in old age, the cellular mechanism is largely unknown. Autophagy is a major cellular lysosomal degradation pathway of bulk material, and levels are known to fall with age. In this study, we describe a novel role for autophagy in CD8(+) T cell memory formation. Mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection. Interestingly, autophagy levels were diminished in CD8(+) T cells from aged mice. We could rejuvenate CD8(+) T cell responses in elderly mice in an autophagy dependent manner using the compound spermidine. This study reveals a cell intrinsic explanation for poor CD8(+) T cell memory in the elderly and potentially offers novel immune modulators to improve aged immunity. |
| spellingShingle | Puleston, D Zhang, H Powell, T Lipina, E Sims, S Panse, I Watson, A Cerundolo, V Townsend, A Klenerman, P Simon, A Autophagy is a critical regulator of memory CD8(+) T cell formation. |
| title | Autophagy is a critical regulator of memory CD8(+) T cell formation. |
| title_full | Autophagy is a critical regulator of memory CD8(+) T cell formation. |
| title_fullStr | Autophagy is a critical regulator of memory CD8(+) T cell formation. |
| title_full_unstemmed | Autophagy is a critical regulator of memory CD8(+) T cell formation. |
| title_short | Autophagy is a critical regulator of memory CD8(+) T cell formation. |
| title_sort | autophagy is a critical regulator of memory cd8 t cell formation |
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