Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection

Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection

<h4>Objective</h4> <p>Long-acting rilpivirine is a candidate for pre-exposure prophylaxis (PrEP) for prevention of HIV-1 infection. However, rilpivirine resistance mutations at reverse transcriptase codon 138 (RT-E138X) occur naturally in a minority of HIV-1-infected persons; in p...

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Main Authors: Gatanaga, H, Brumme, Z, Adland, E, Reyes-Terán, G, Avila-Rios, S, Mejía-Villatoro, C, Hayashida, T, Chikata, T, Van Tran, G, Van Nguyen, K, Meza, R, Palou, E, Valenzuela-Ponce, H, Pascale, J, Porras-Cortés, G, Manzanero, M, Lee, G, Martin, J, Carrington, M, John, M, Mallal, S, Poon, A, Goulder, P, Takiguchi, M, Oka, S
Format: Journal article
Language:English
Published: Lippincott, Williams & Wilkins 2017

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