Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.
We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that incre...
| Huvudupphovsmän: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
2008
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| _version_ | 1826286208921108480 |
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| author | Jaeger, E Webb, E Howarth, K Carvajal-Carmona, L Rowan, A Broderick, P Walther, A Spain, S Pittman, A Kemp, Z Sullivan, K Heinimann, K Lubbe, S Domingo, E Barclay, E Martin, L Gorman, M Chandler, I Vijayakrishnan, J Wood, W Papaemmanuil, E Penegar, S Qureshi, M Farrington, S Tenesa, A |
| author_facet | Jaeger, E Webb, E Howarth, K Carvajal-Carmona, L Rowan, A Broderick, P Walther, A Spain, S Pittman, A Kemp, Z Sullivan, K Heinimann, K Lubbe, S Domingo, E Barclay, E Martin, L Gorman, M Chandler, I Vijayakrishnan, J Wood, W Papaemmanuil, E Penegar, S Qureshi, M Farrington, S Tenesa, A |
| author_sort | Jaeger, E |
| collection | OXFORD |
| description | We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)). |
| first_indexed | 2024-03-07T01:40:22Z |
| format | Journal article |
| id | oxford-uuid:96a4c82c-cefb-46d6-9d82-811d7f9a68dc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:40:22Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:96a4c82c-cefb-46d6-9d82-811d7f9a68dc2022-03-26T23:54:21ZCommon genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:96a4c82c-cefb-46d6-9d82-811d7f9a68dcEnglishSymplectic Elements at Oxford2008Jaeger, EWebb, EHowarth, KCarvajal-Carmona, LRowan, ABroderick, PWalther, ASpain, SPittman, AKemp, ZSullivan, KHeinimann, KLubbe, SDomingo, EBarclay, EMartin, LGorman, MChandler, IVijayakrishnan, JWood, WPapaemmanuil, EPenegar, SQureshi, MFarrington, STenesa, AWe mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE1), GREM1 and FMN1. We hypothesized that the CRAC1 locus harbored low-penetrance variants that increased CRC risk in the general population. In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14)). |
| spellingShingle | Jaeger, E Webb, E Howarth, K Carvajal-Carmona, L Rowan, A Broderick, P Walther, A Spain, S Pittman, A Kemp, Z Sullivan, K Heinimann, K Lubbe, S Domingo, E Barclay, E Martin, L Gorman, M Chandler, I Vijayakrishnan, J Wood, W Papaemmanuil, E Penegar, S Qureshi, M Farrington, S Tenesa, A Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. |
| title | Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. |
| title_full | Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. |
| title_fullStr | Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. |
| title_full_unstemmed | Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. |
| title_short | Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. |
| title_sort | common genetic variants at the crac1 hmps locus on chromosome 15q13 3 influence colorectal cancer risk |
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