Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency.

Míreanna comhchosúla

• Epiblastic Cited2 function explains pleiotropy and penetrance of cardiac malformation resulting from its deficiency
  de réir: Macdonald, S, et al.
  Foilsithe / Cruthaithe: (2007)
• Mechanisms of cardiac pleiotropy in Cited2 deficiency
  de réir: MacDonald, S, et al.
  Foilsithe / Cruthaithe: (2008)
• Intraembryonic Cited2 is necessary for normal cardiac development and left-right patterning
  de réir: MacDonald, S, et al.
  Foilsithe / Cruthaithe: (2006)
• Cardiac-specific deletion of Cited2 reveals a cell autonomous role in positively regulating vegfa expression in the developing heart
  de réir: MacDonald, S, et al.
  Foilsithe / Cruthaithe: (2007)
• Cited2 haploinsufficiency is associated with congenital heart defects in mouse and man: Introducing the GO-CHD Study
  de réir: Bentham, J, et al.
  Foilsithe / Cruthaithe: (2006)