Intestinal stromal cells in mucosal immunity and homeostasis.
A growing body of evidence suggests that non-hematopoietic stromal cells of the intestine have multiple roles in immune responses and inflammation at this mucosal site. Despite this, many still consider gut stromal cells as passive structural entities, with past research focused heavily on their rol...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2013
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| _version_ | 1797083367428063232 |
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| author | Owens, B Simmons, A |
| author_facet | Owens, B Simmons, A |
| author_sort | Owens, B |
| collection | OXFORD |
| description | A growing body of evidence suggests that non-hematopoietic stromal cells of the intestine have multiple roles in immune responses and inflammation at this mucosal site. Despite this, many still consider gut stromal cells as passive structural entities, with past research focused heavily on their roles in fibrosis, tumor progression, and wound healing, rather than their contributions to immune function. In this review, we discuss our current knowledge of stromal cells in intestinal immunity, highlighting the many immunological axes in which stromal cells have a functional role. We also consider emerging data that broaden the potential scope of their contribution to immunity in the gut and argue that these so-called "non-immune" cells are reclassified in light of their diverse contributions to intestinal innate immunity and the maintenance of mucosal homeostasis. |
| first_indexed | 2024-03-07T01:40:46Z |
| format | Journal article |
| id | oxford-uuid:96c696cf-6806-4311-b891-6b3225f7ee0a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:40:46Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:96c696cf-6806-4311-b891-6b3225f7ee0a2022-03-26T23:55:10ZIntestinal stromal cells in mucosal immunity and homeostasis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:96c696cf-6806-4311-b891-6b3225f7ee0aEnglishSymplectic Elements at Oxford2013Owens, BSimmons, AA growing body of evidence suggests that non-hematopoietic stromal cells of the intestine have multiple roles in immune responses and inflammation at this mucosal site. Despite this, many still consider gut stromal cells as passive structural entities, with past research focused heavily on their roles in fibrosis, tumor progression, and wound healing, rather than their contributions to immune function. In this review, we discuss our current knowledge of stromal cells in intestinal immunity, highlighting the many immunological axes in which stromal cells have a functional role. We also consider emerging data that broaden the potential scope of their contribution to immunity in the gut and argue that these so-called "non-immune" cells are reclassified in light of their diverse contributions to intestinal innate immunity and the maintenance of mucosal homeostasis. |
| spellingShingle | Owens, B Simmons, A Intestinal stromal cells in mucosal immunity and homeostasis. |
| title | Intestinal stromal cells in mucosal immunity and homeostasis. |
| title_full | Intestinal stromal cells in mucosal immunity and homeostasis. |
| title_fullStr | Intestinal stromal cells in mucosal immunity and homeostasis. |
| title_full_unstemmed | Intestinal stromal cells in mucosal immunity and homeostasis. |
| title_short | Intestinal stromal cells in mucosal immunity and homeostasis. |
| title_sort | intestinal stromal cells in mucosal immunity and homeostasis |
| work_keys_str_mv | AT owensb intestinalstromalcellsinmucosalimmunityandhomeostasis AT simmonsa intestinalstromalcellsinmucosalimmunityandhomeostasis |