Stem and progenitor cell dysfunction in human trisomies
Trisomy 21, the commonest constitutional aneuploidy in humans, causes profound perturbation of stem and progenitor cell growth, which is both cell context dependent and developmental stage specific and mediated by complex genetic mechanisms beyond increased Hsa21 gene dosage. While proliferation of...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
EMBO Press
2014
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