Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.

Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.

Sulphonylurea drugs are the therapy of choice for treating neonatal diabetes (ND) caused by mutations in the ATP-sensitive K(+) channel (KATP channel). We investigated the interactions between MgATP, MgADP, and the sulphonylurea gliclazide with KATP channels expressed in Xenopus oocytes. In the abse...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Proks, P, De Wet, H, Ashcroft, F
التنسيق:	Journal article
اللغة:	English
منشور في:	2013

مواد مشابهة

Phentolamine block of ATP-sensitive K+ channels does not involve interaction with the sulphonylurea receptor, SUR1.
حسب: Proks, P, وآخرون
منشور في: (1997)

Interaction of MgATP with the sulphonylurea subunit activates ATP sensitive K-channels receptor
حسب: Gribble, F, وآخرون
منشور في: (1998)

How ATP inhibits the open K(ATP) channel.
حسب: Craig, T, وآخرون
منشور في: (2008)

Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.
حسب: Reimann, F, وآخرون
منشور في: (2003)

Mechanism of K-ATP channel inhibition by ATP
حسب: Ashcroft, F, وآخرون
منشور في: (1998)

Molecular analysis of ATP-sensitive K channel gating and implications for channel inhibition by ATP.
حسب: Trapp, S, وآخرون
منشور في: (1998)

The extent of K-ATP channel block by MgATP correlates with the clinical phenotype caused by gain-of-function KCNJ11 mutations
حسب: Proks, R, وآخرون
منشور في: (2005)

Inhibition of cloned K-ATP channels by stilbene disulphonates
حسب: Proks, P, وآخرون
منشور في: (2000)

Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1.
حسب: Proks, P, وآخرون
منشور في: (2010)

High-affinity block of K-ATP channels of mouse isolated pancreatic beta-cells but not rat heart or arterial smooth muscle cells by the sulphonylurea gliclazide
حسب: Jones, P, وآخرون
منشور في: (2001)

Truncation of Kir6.2 produces ATP-sensitive K+ channels in the absence of the sulphonylurea receptor.
حسب: Tucker, S, وآخرون
منشور في: (1997)

Gating and ATP-sensitivity of the cloned beta-cell K-ATP channel
حسب: Trapp, S, وآخرون
منشور في: (1998)

Neonatal Diabetes Caused by Activating Mutations in the Sulphonylurea Receptor
حسب: Peter Proks
منشور في: (2013-06-01)

Modeling K(ATP) channel gating and its regulation.
حسب: Proks, P, وآخرون
منشور في: (2009)

Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells.
حسب: Bokvist, K, وآخرون
منشور في: (1999)

Inhibition of ATP-sensitive potassium channels by haloperidol.
حسب: Yang, S, وآخرون
منشور في: (2004)

Modification of K-ATP channels in pancreatic beta-cells by trypsin.
حسب: Proks, P, وآخرون
منشور في: (1993)

Interaction of stilbene disulphonates with cloned K(ATP) channels.
حسب: Proks, P, وآخرون
منشور في: (2001)

Functional effects of KCNJ11 mutations causing neonatal diabetes: enhanced activation by MgATP.
حسب: Proks, P, وآخرون
منشور في: (2005)

Interaction of vanadate with the cloned beta cell K(ATP) channel.
حسب: Proks, P, وآخرون
منشور في: (1999)

Modulation of gating of the cloned beta-cell K-ATP channel
حسب: Proks, P, وآخرون
منشور في: (1998)

Dynamic sensitivity of K-ATP channels to ATP
حسب: Loussouarn, G, وآخرون
منشور في: (2001)

EFFECTS OF TRYPSIN ON ATP-DEPENDENT-K+ CHANNELS FROM PANCREATIC BETA-CELLS
حسب: Proks, P, وآخرون
منشور في: (1992)

Molecular determinants of KATP channel inhibition by ATP.
حسب: Tucker, S, وآخرون
منشور في: (1998)

Expression of functionally active ATP-sensitive K-channels in insect cells using baculovirus.
حسب: Mikhailov, M, وآخرون
منشور في: (1998)

Dynamic sensitivity of ATP-sensitive K(+) channels to ATP.
حسب: Loussouarn, G, وآخرون
منشور في: (2001)

A mouse model of neonatal diabetes caused by the K-ATP channel mutation Kir6.2-V59M
حسب: Girard, C, وآخرون
منشور في: (2008)

Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-azido-ATP.
حسب: Tanabe, K, وآخرون
منشور في: (1999)

The Yin and Yang of the K(ATP) channel.
حسب: Ashcroft, F
منشور في: (2000)

THE EFFECT OF INTRACELLULAR PROTONS ON ATP-SENSITIVE K+ CHANNELS IN MOUSE PANCREATIC BETA-CELLS
حسب: Proks, P, وآخرون
منشور في: (1993)

Two types of gating in inward rectifiers: The case of the K-ATP channel.
حسب: Proks, P, وآخرون
منشور في: (2001)

Mechanism of ATP-sensitive K channel inhibition by sulfhydryl modification.
حسب: Trapp, S, وآخرون
منشور في: (1998)

Properties and functions of ATP-sensitive K-channels.
حسب: Ashcroft, S, وآخرون
منشور في: (1990)

Metabolic inhibition and low internal ATP activate K-ATP channels in rat dopaminergic substantia nigra neurones.
حسب: Röper, J, وآخرون
منشور في: (1995)

Effects of intracellular pH on ATP-sensitive K+ channels in mouse pancreatic beta-cells.
حسب: Proks, P, وآخرون
منشور في: (1994)

THE EFFECT OF INTRACELLULAR PH ON ATP-SENSITIVE K+ CHANNELS IN ISOLATED MOUSE PANCREATIC BETA-CELLS
حسب: Proks, P, وآخرون
منشور في: (1993)

Mice expressing a human K(ATP) channel mutation have altered channel ATP sensitivity but no cardiac abnormalities.
حسب: Clark, R, وآخرون
منشور في: (2012)

Mice expressing a human K ATP channel mutation have altered channel ATP sensitivity but no cardiac abnormalities
حسب: Clark, R, وآخرون
منشور في: (2012)

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.
حسب: Proks, P, وآخرون
منشور في: (1999)

Differential metabolic and nucleotide sensitivity of beta-cell and cardiac K-ATP channels
حسب: Vedovato, N, وآخرون
منشور في: (2018)