Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.

A major cause of aging is thought to result from the cumulative effects of cell loss over time. In yeast, caloric restriction (CR) delays aging by activating the Sir2 deacetylase. Here we show that expression of mammalian Sir2 (SIRT1) is induced in CR rats as well as in human cells that are treated...

書目詳細資料
Main Authors:	Cohen, H, Miller, C, Bitterman, K, Wall, N, Hekking, B, Kessler, B, Howitz, K, Gorospe, M, de Cabo, R, Sinclair, D
格式:	Journal article
語言:	English
出版:	2004

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