Characterization of German penicillin non-susceptible serotype 23F pneumococci using multilocus sequence typing.
Three nationwide multicentre studies (n = 5071) showed an increase in antibiotic resistance in pneumococci in Germany. Serotype 23F was the predominant serotype (n = 45, 22.4 %), followed by 6B (n = 30, 14.9 %) and 9V (n = 19, 9.5 %). Multilocus sequence typing was used to characterize 45 serotype 2...
| Main Authors: | , , , , , , |
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| Format: | Conference item |
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2003
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| _version_ | 1826286250015850496 |
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| author | Reinert, R Muckel, S Al-Lahham, A Spratt, BG Brueggemann, A Hakenbeck, R Lütticken, R |
| author_facet | Reinert, R Muckel, S Al-Lahham, A Spratt, BG Brueggemann, A Hakenbeck, R Lütticken, R |
| author_sort | Reinert, R |
| collection | OXFORD |
| description | Three nationwide multicentre studies (n = 5071) showed an increase in antibiotic resistance in pneumococci in Germany. Serotype 23F was the predominant serotype (n = 45, 22.4 %), followed by 6B (n = 30, 14.9 %) and 9V (n = 19, 9.5 %). Multilocus sequence typing was used to characterize 45 serotype 23F strains with reduced penicillin susceptibility. The Spanish(23F)-1 clone [profile 4-4-2-4-4-1-1, sequence type (ST) 81] contributes significantly to the emergence of penicillin resistance in Germany (n = 21, 46.7 % of all penicillin non-susceptible serotype 23F isolates). Isolates of ST 277 (profile 7-13-8-6-6-12-8), which has been found previously in the Netherlands, are also observed, particularly in western Germany (n = 8, 17.8 %). A high proportion of strains (n = 11, 24.4 %) have sequence types that have not been reported to date from other countries (STs 353-362). The major penicillin-resistant clones are present in Germany, a country with relatively low levels of beta-lactam resistance. |
| first_indexed | 2024-03-07T01:40:58Z |
| format | Conference item |
| id | oxford-uuid:96d384d8-4d13-4016-8648-17ac51ac9ddb |
| institution | University of Oxford |
| last_indexed | 2024-03-07T01:40:58Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:96d384d8-4d13-4016-8648-17ac51ac9ddb2022-03-26T23:55:34ZCharacterization of German penicillin non-susceptible serotype 23F pneumococci using multilocus sequence typing.Conference itemhttp://purl.org/coar/resource_type/c_5794uuid:96d384d8-4d13-4016-8648-17ac51ac9ddbSymplectic Elements at Oxford2003Reinert, RMuckel, SAl-Lahham, ASpratt, BGBrueggemann, AHakenbeck, RLütticken, RThree nationwide multicentre studies (n = 5071) showed an increase in antibiotic resistance in pneumococci in Germany. Serotype 23F was the predominant serotype (n = 45, 22.4 %), followed by 6B (n = 30, 14.9 %) and 9V (n = 19, 9.5 %). Multilocus sequence typing was used to characterize 45 serotype 23F strains with reduced penicillin susceptibility. The Spanish(23F)-1 clone [profile 4-4-2-4-4-1-1, sequence type (ST) 81] contributes significantly to the emergence of penicillin resistance in Germany (n = 21, 46.7 % of all penicillin non-susceptible serotype 23F isolates). Isolates of ST 277 (profile 7-13-8-6-6-12-8), which has been found previously in the Netherlands, are also observed, particularly in western Germany (n = 8, 17.8 %). A high proportion of strains (n = 11, 24.4 %) have sequence types that have not been reported to date from other countries (STs 353-362). The major penicillin-resistant clones are present in Germany, a country with relatively low levels of beta-lactam resistance. |
| spellingShingle | Reinert, R Muckel, S Al-Lahham, A Spratt, BG Brueggemann, A Hakenbeck, R Lütticken, R Characterization of German penicillin non-susceptible serotype 23F pneumococci using multilocus sequence typing. |
| title | Characterization of German penicillin non-susceptible serotype 23F pneumococci using multilocus sequence typing. |
| title_full | Characterization of German penicillin non-susceptible serotype 23F pneumococci using multilocus sequence typing. |
| title_fullStr | Characterization of German penicillin non-susceptible serotype 23F pneumococci using multilocus sequence typing. |
| title_full_unstemmed | Characterization of German penicillin non-susceptible serotype 23F pneumococci using multilocus sequence typing. |
| title_short | Characterization of German penicillin non-susceptible serotype 23F pneumococci using multilocus sequence typing. |
| title_sort | characterization of german penicillin non susceptible serotype 23f pneumococci using multilocus sequence typing |
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