Fumarate hydratase deficiency and cancer: activation of hypoxia signaling?
Molecular genetic analysis of hereditary leiomyomatosis and renal cell cancer (HLRCC) unexpectedly revealed germline defects in the gene encoding the Krebs cycle enzyme fumarate hydratase (FH), stimulating great interest in the underlying mechanism of oncogenesis. It has been proposed that the assoc...
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| 格式: | Journal article |
| 语言: | English |
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2007
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