Single-molecule imaging of DNA gyrase activity in living Escherichia coli

Bacterial DNA gyrase introduces negative supercoils into chromosomal DNA and relaxes positive supercoils introduced by replication and transiently by transcription. Removal of these positive supercoils is essential for replication fork progression and for the overall unlinking of the two duplex DNA...

Full description

Bibliographic Details
Main Authors: Stracy, M, Wollman, A, Kaja, E, Gapinski, J, Lee, J, Leek, V, McKie, S, Mitchenall, L, Maxwell, A, Sherratt, D, Leake, M, Zawadzki, P
Format: Journal article
Language:English
Published: Oxford University Press 2018