Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58.

Impact of salt bridges on the equilibrium binding and adhesion of human CD2 and CD58.

This study describes quantitative investigations of the impact of single charge mutations on equilibrium binding, kinetics, and the adhesion strength of the CD2-CD58 interaction. Previously steered molecular dynamics simulations guided the selection of the charge mutants investigated, which include...

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Bibliographic Details
Main Authors:	Bayas, M, Kearney, A, Avramovic, A, Van Der Merwe, P, Leckband, D
Format:	Journal article
Language:	English
Published:	2007

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