Discovery of unconventional kinetochores in kinetoplastids.
The kinetochore is the macromolecular protein complex that directs chromosome segregation in eukaryotes. It has been widely assumed that the core kinetochore consists of proteins that are common to all eukaryotes. However, no conventional kinetochore components have been identified in any kinetoplas...
| Үндсэн зохиолчид: | , |
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| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
2014
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| _version_ | 1826286264389730304 |
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| author | Akiyoshi, B Gull, K |
| author_facet | Akiyoshi, B Gull, K |
| author_sort | Akiyoshi, B |
| collection | OXFORD |
| description | The kinetochore is the macromolecular protein complex that directs chromosome segregation in eukaryotes. It has been widely assumed that the core kinetochore consists of proteins that are common to all eukaryotes. However, no conventional kinetochore components have been identified in any kinetoplastid genome, thus challenging this assumption of universality. Here, we report the identification of 19 kinetochore proteins (KKT1-19) in Trypanosoma brucei. The majority is conserved among kinetoplastids, but none of them has detectable homology to conventional kinetochore proteins. These proteins instead have a variety of features not found in conventional kinetochore proteins. We propose that kinetoplastids build kinetochores using a distinct set of proteins. These findings provide important insights into the longstanding problem of the position of the root of the eukaryotic tree of life. |
| first_indexed | 2024-03-07T01:41:12Z |
| format | Journal article |
| id | oxford-uuid:96e6cbda-5190-40e6-abfe-a91eae09ab4f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:41:12Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:96e6cbda-5190-40e6-abfe-a91eae09ab4f2022-03-26T23:56:03ZDiscovery of unconventional kinetochores in kinetoplastids.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:96e6cbda-5190-40e6-abfe-a91eae09ab4fEnglishSymplectic Elements at Oxford2014Akiyoshi, BGull, KThe kinetochore is the macromolecular protein complex that directs chromosome segregation in eukaryotes. It has been widely assumed that the core kinetochore consists of proteins that are common to all eukaryotes. However, no conventional kinetochore components have been identified in any kinetoplastid genome, thus challenging this assumption of universality. Here, we report the identification of 19 kinetochore proteins (KKT1-19) in Trypanosoma brucei. The majority is conserved among kinetoplastids, but none of them has detectable homology to conventional kinetochore proteins. These proteins instead have a variety of features not found in conventional kinetochore proteins. We propose that kinetoplastids build kinetochores using a distinct set of proteins. These findings provide important insights into the longstanding problem of the position of the root of the eukaryotic tree of life. |
| spellingShingle | Akiyoshi, B Gull, K Discovery of unconventional kinetochores in kinetoplastids. |
| title | Discovery of unconventional kinetochores in kinetoplastids. |
| title_full | Discovery of unconventional kinetochores in kinetoplastids. |
| title_fullStr | Discovery of unconventional kinetochores in kinetoplastids. |
| title_full_unstemmed | Discovery of unconventional kinetochores in kinetoplastids. |
| title_short | Discovery of unconventional kinetochores in kinetoplastids. |
| title_sort | discovery of unconventional kinetochores in kinetoplastids |
| work_keys_str_mv | AT akiyoshib discoveryofunconventionalkinetochoresinkinetoplastids AT gullk discoveryofunconventionalkinetochoresinkinetoplastids |