Nilabh Shastri – Towards understanding classical and non-classical MHC-I antigen processing and presentation
<p>Major histocompatibility complex (MHC-I) peptide antigen processing and presentation has experienced a revived interest in the context of immuno oncology, immune surveillance escape by pathogen mutations and technical advances that accelerate vaccine design. This sheds new light on the disc...
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| Format: | Journal article |
| Language: | English |
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Elsevier
2022
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| _version_ | 1797108949316534272 |
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| author | Kessler, BM |
| author_facet | Kessler, BM |
| author_sort | Kessler, BM |
| collection | OXFORD |
| description | <p>Major histocompatibility complex (MHC-I) peptide antigen processing and presentation has experienced a revived interest in the context of immuno oncology, immune surveillance escape by pathogen mutations and technical advances that accelerate vaccine design. This sheds new light on the discoveries made by Nilabh Shastri and colleagues that includes the characterisation of cryptic MHC-I peptide antigen epitopes derived from untranslated regions and the N-terminal trimming of peptide antigen precursors by the aminopeptidase ERAAP (ERAP1/2 / ARTS1/LRAP) in the endoplasmic reticulum (ER) prior to the complete assembly of MHC-I complexes and their subsequent exposure to the cell surface. These scientific findings have important implications for developing novel therapeutic approaches in immunotherapy and modern vaccine design.</p> |
| first_indexed | 2024-03-07T07:35:08Z |
| format | Journal article |
| id | oxford-uuid:96e86628-2144-4214-b6b1-499e236b8c5e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:35:08Z |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:96e86628-2144-4214-b6b1-499e236b8c5e2023-02-23T15:21:06ZNilabh Shastri – Towards understanding classical and non-classical MHC-I antigen processing and presentationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:96e86628-2144-4214-b6b1-499e236b8c5eEnglishSymplectic ElementsElsevier2022Kessler, BM<p>Major histocompatibility complex (MHC-I) peptide antigen processing and presentation has experienced a revived interest in the context of immuno oncology, immune surveillance escape by pathogen mutations and technical advances that accelerate vaccine design. This sheds new light on the discoveries made by Nilabh Shastri and colleagues that includes the characterisation of cryptic MHC-I peptide antigen epitopes derived from untranslated regions and the N-terminal trimming of peptide antigen precursors by the aminopeptidase ERAAP (ERAP1/2 / ARTS1/LRAP) in the endoplasmic reticulum (ER) prior to the complete assembly of MHC-I complexes and their subsequent exposure to the cell surface. These scientific findings have important implications for developing novel therapeutic approaches in immunotherapy and modern vaccine design.</p> |
| spellingShingle | Kessler, BM Nilabh Shastri – Towards understanding classical and non-classical MHC-I antigen processing and presentation |
| title | Nilabh Shastri – Towards understanding classical and non-classical MHC-I antigen processing and presentation |
| title_full | Nilabh Shastri – Towards understanding classical and non-classical MHC-I antigen processing and presentation |
| title_fullStr | Nilabh Shastri – Towards understanding classical and non-classical MHC-I antigen processing and presentation |
| title_full_unstemmed | Nilabh Shastri – Towards understanding classical and non-classical MHC-I antigen processing and presentation |
| title_short | Nilabh Shastri – Towards understanding classical and non-classical MHC-I antigen processing and presentation |
| title_sort | nilabh shastri towards understanding classical and non classical mhc i antigen processing and presentation |
| work_keys_str_mv | AT kesslerbm nilabhshastritowardsunderstandingclassicalandnonclassicalmhciantigenprocessingandpresentation |