Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies.
The role of Fas ligand (FasL) in programmed cell death via interaction with its receptor Fas is well characterized. It has been proposed that expression of FasL can confer immune privilege to some organs, allowing them to kill infiltrating lymphocytes and inflammatory cells. However, a number of stu...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2002
|
| _version_ | 1826286274663677952 |
|---|---|
| author | Simon, A Gallimore, A Jones, E Sawitzki, B Cerundolo, V Screaton, G |
| author_facet | Simon, A Gallimore, A Jones, E Sawitzki, B Cerundolo, V Screaton, G |
| author_sort | Simon, A |
| collection | OXFORD |
| description | The role of Fas ligand (FasL) in programmed cell death via interaction with its receptor Fas is well characterized. It has been proposed that expression of FasL can confer immune privilege to some organs, allowing them to kill infiltrating lymphocytes and inflammatory cells. However, a number of studies have shown that when tumors or transplants express FasL, rejection often occurs as a consequence of proinflammatory functions of FasL. Here we demonstrate that FasL elicits tumor immunity in a murine melanoma model with weak immunogenicity and low expression of major histocompatibility complex (MHC) class I. We show that protected mice recognize melanocyte differentiation self-antigens. Importantly, tumor immunity is mediated by antibodies, as it can be transferred by serum from protected mice. |
| first_indexed | 2024-03-07T01:41:20Z |
| format | Journal article |
| id | oxford-uuid:96f24992-f935-4017-a247-6f182f074618 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:41:20Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:96f24992-f935-4017-a247-6f182f0746182022-03-26T23:56:21ZFas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:96f24992-f935-4017-a247-6f182f074618EnglishSymplectic Elements at Oxford2002Simon, AGallimore, AJones, ESawitzki, BCerundolo, VScreaton, GThe role of Fas ligand (FasL) in programmed cell death via interaction with its receptor Fas is well characterized. It has been proposed that expression of FasL can confer immune privilege to some organs, allowing them to kill infiltrating lymphocytes and inflammatory cells. However, a number of studies have shown that when tumors or transplants express FasL, rejection often occurs as a consequence of proinflammatory functions of FasL. Here we demonstrate that FasL elicits tumor immunity in a murine melanoma model with weak immunogenicity and low expression of major histocompatibility complex (MHC) class I. We show that protected mice recognize melanocyte differentiation self-antigens. Importantly, tumor immunity is mediated by antibodies, as it can be transferred by serum from protected mice. |
| spellingShingle | Simon, A Gallimore, A Jones, E Sawitzki, B Cerundolo, V Screaton, G Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies. |
| title | Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies. |
| title_full | Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies. |
| title_fullStr | Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies. |
| title_full_unstemmed | Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies. |
| title_short | Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies. |
| title_sort | fas ligand breaks tolerance to self antigens and induces tumor immunity mediated by antibodies |
| work_keys_str_mv | AT simona fasligandbreakstolerancetoselfantigensandinducestumorimmunitymediatedbyantibodies AT gallimorea fasligandbreakstolerancetoselfantigensandinducestumorimmunitymediatedbyantibodies AT jonese fasligandbreakstolerancetoselfantigensandinducestumorimmunitymediatedbyantibodies AT sawitzkib fasligandbreakstolerancetoselfantigensandinducestumorimmunitymediatedbyantibodies AT cerundolov fasligandbreakstolerancetoselfantigensandinducestumorimmunitymediatedbyantibodies AT screatong fasligandbreakstolerancetoselfantigensandinducestumorimmunitymediatedbyantibodies |