A genome-wide association meta-analysis identifies new childhood obesity loci
Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 1...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
2012
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| _version_ | 1826286276478763008 |
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| author | Bradfield, J Taal, H Timpson, N Scherag, A Lecoeur, C Warrington, N Hypponen, E Holst, C Valcarcel, B Thiering, E Salem, R Schumacher, F Cousminer, D Sleiman, P Zhao, J Berkowitz, R Vimaleswaran, K Jarick, I Pennell, C Evans, D St Pourcain, B Berry, D Mook-Kanamori, DO Hofman, A Rivadeneira, F |
| author_facet | Bradfield, J Taal, H Timpson, N Scherag, A Lecoeur, C Warrington, N Hypponen, E Holst, C Valcarcel, B Thiering, E Salem, R Schumacher, F Cousminer, D Sleiman, P Zhao, J Berkowitz, R Vimaleswaran, K Jarick, I Pennell, C Evans, D St Pourcain, B Berry, D Mook-Kanamori, DO Hofman, A Rivadeneira, F |
| author_sort | Bradfield, J |
| collection | OXFORD |
| description | Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10 -6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10 -9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10 -9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI. © 2012 Nature America, Inc. All rights reserved. |
| first_indexed | 2024-03-07T01:41:22Z |
| format | Journal article |
| id | oxford-uuid:96f4bbd6-9965-4488-bd10-c99d0e45ba6b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:41:22Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:96f4bbd6-9965-4488-bd10-c99d0e45ba6b2022-03-26T23:56:31ZA genome-wide association meta-analysis identifies new childhood obesity lociJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:96f4bbd6-9965-4488-bd10-c99d0e45ba6bEnglishSymplectic Elements at Oxford2012Bradfield, JTaal, HTimpson, NScherag, ALecoeur, CWarrington, NHypponen, EHolst, CValcarcel, BThiering, ESalem, RSchumacher, FCousminer, DSleiman, PZhao, JBerkowitz, RVimaleswaran, KJarick, IPennell, CEvans, DSt Pourcain, BBerry, DMook-Kanamori, DOHofman, ARivadeneira, FMultiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10 -6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10 -9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10 -9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI. © 2012 Nature America, Inc. All rights reserved. |
| spellingShingle | Bradfield, J Taal, H Timpson, N Scherag, A Lecoeur, C Warrington, N Hypponen, E Holst, C Valcarcel, B Thiering, E Salem, R Schumacher, F Cousminer, D Sleiman, P Zhao, J Berkowitz, R Vimaleswaran, K Jarick, I Pennell, C Evans, D St Pourcain, B Berry, D Mook-Kanamori, DO Hofman, A Rivadeneira, F A genome-wide association meta-analysis identifies new childhood obesity loci |
| title | A genome-wide association meta-analysis identifies new childhood obesity loci |
| title_full | A genome-wide association meta-analysis identifies new childhood obesity loci |
| title_fullStr | A genome-wide association meta-analysis identifies new childhood obesity loci |
| title_full_unstemmed | A genome-wide association meta-analysis identifies new childhood obesity loci |
| title_short | A genome-wide association meta-analysis identifies new childhood obesity loci |
| title_sort | genome wide association meta analysis identifies new childhood obesity loci |
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