USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism

USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism

Interferon-induced ubiquitin (Ub)-like modifier ISG15 covalently modifies host and viral proteins to restrict viral infections. Its function is counteracted by the canonical deISGylase USP18 or Ub-specific protease 18. Notwithstanding indications for the existence of other ISG15 cross-reactive prote...

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Bibliographic Details
Main Authors: Gan, J, Pinto-Fernández, A, Flierman, D, Akkermans, JJLL, O'Brien, DP, Greenwood, H, Scott, HC, Fritz, G, Knobeloch, K-P, Neefjes, J, van Dam, H, Ovaa, H, Ploegh, HL, Kessler, BM, Geurink, PP, Sapmaz, A
Format: Journal article
Language:English
Published: National Academy of Sciences 2023

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