Glucocorticoid receptor isoforms direct distinct mitochondrial programs to regulate ATP production

The glucocorticoid receptor (GR), a nuclear receptor and major drug target, has a highly conserved minor splice variant, GRγ, which differs by a single arginine within the DNA binding domain. GRγ, which comprises 10% of all GR transcripts, is constitutively expressed and tightly conserved through ma...

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Bibliographic Details
Main Authors: Morgan, D, Poolman, T, Williamson, A, Wang, Z, Clark, N, Ma'Ayan, A, Whetton, A, Brass, A, Matthews, L, Ray, D
Format: Journal article
Language:English
Published: Nature Publishing Group 2016