Estimating the reduced scattering coefficient of turbid media using spatially offset raman spectroscopy
We propose a new method for estimating the reduced scattering coefficient, μs′, of turbid homogeneous samples using Spatially Offset Raman Spectroscopy (SORS). The concept is based around the variation of Raman signal with SORS spatial offset that is strongly μs′-dependent, as such, permitting the d...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2021
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| _version_ | 1797107046741442560 |
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| author | Mosca, S Dey, P Salimi, M Gardner, B Palombo, F Stone, N Matousek, P |
| author_facet | Mosca, S Dey, P Salimi, M Gardner, B Palombo, F Stone, N Matousek, P |
| author_sort | Mosca, S |
| collection | OXFORD |
| description | We propose a new method for estimating the reduced scattering coefficient, μs′, of turbid homogeneous samples using Spatially Offset Raman Spectroscopy (SORS). The concept is based around the variation of Raman signal with SORS spatial offset that is strongly μs′-dependent, as such, permitting the determination of μs′. The evaluation is carried out under the assumptions that absorption is negligible at the laser and Raman wavelengths and μs′ is approximately the same for those two wavelengths. These conditions are often satisfied for samples analyzed in the NIR region of the spectrum where SORS is traditionally deployed. Through a calibration procedure on a PTFE model sample, it was possible to estimate the μs′ coefficient of different turbid samples with an error (RMSEP) below 18%. The knowledge of μs′ in the NIR range is highly valuable for facilitating accurate numerical simulations to optimize illumination and collection geometries in SORS, to derive in-depth information about the properties of SORS measurements or in other photon applications, dependent on photon propagation in turbid media with general impact across fields such as biomedical, pharmaceutical, security, forensic, and cultural sciences. |
| first_indexed | 2024-03-07T07:11:03Z |
| format | Journal article |
| id | oxford-uuid:9715e1ea-a9d4-40b4-9f56-8177fa487b01 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:11:03Z |
| publishDate | 2021 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:9715e1ea-a9d4-40b4-9f56-8177fa487b012022-06-23T12:48:53ZEstimating the reduced scattering coefficient of turbid media using spatially offset raman spectroscopyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9715e1ea-a9d4-40b4-9f56-8177fa487b01EnglishSymplectic ElementsAmerican Chemical Society2021Mosca, SDey, PSalimi, MGardner, BPalombo, FStone, NMatousek, PWe propose a new method for estimating the reduced scattering coefficient, μs′, of turbid homogeneous samples using Spatially Offset Raman Spectroscopy (SORS). The concept is based around the variation of Raman signal with SORS spatial offset that is strongly μs′-dependent, as such, permitting the determination of μs′. The evaluation is carried out under the assumptions that absorption is negligible at the laser and Raman wavelengths and μs′ is approximately the same for those two wavelengths. These conditions are often satisfied for samples analyzed in the NIR region of the spectrum where SORS is traditionally deployed. Through a calibration procedure on a PTFE model sample, it was possible to estimate the μs′ coefficient of different turbid samples with an error (RMSEP) below 18%. The knowledge of μs′ in the NIR range is highly valuable for facilitating accurate numerical simulations to optimize illumination and collection geometries in SORS, to derive in-depth information about the properties of SORS measurements or in other photon applications, dependent on photon propagation in turbid media with general impact across fields such as biomedical, pharmaceutical, security, forensic, and cultural sciences. |
| spellingShingle | Mosca, S Dey, P Salimi, M Gardner, B Palombo, F Stone, N Matousek, P Estimating the reduced scattering coefficient of turbid media using spatially offset raman spectroscopy |
| title | Estimating the reduced scattering coefficient of turbid media using spatially offset raman spectroscopy |
| title_full | Estimating the reduced scattering coefficient of turbid media using spatially offset raman spectroscopy |
| title_fullStr | Estimating the reduced scattering coefficient of turbid media using spatially offset raman spectroscopy |
| title_full_unstemmed | Estimating the reduced scattering coefficient of turbid media using spatially offset raman spectroscopy |
| title_short | Estimating the reduced scattering coefficient of turbid media using spatially offset raman spectroscopy |
| title_sort | estimating the reduced scattering coefficient of turbid media using spatially offset raman spectroscopy |
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