Tumor cells upregulate normoxic HIF-1α in response to doxorubicin

Tumor cells upregulate normoxic HIF-1α in response to doxorubicin

Hypoxia-inducible factor 1 (HIF-1) is a master transcription factor that controls cellular homeostasis. Although its activation benefits normal tissue, HIF-1 activation in tumors is a major risk factor for angiogenesis, therapeutic resistance, and poor prognosis. HIF-1 activity is usually suppressed...

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Bibliographic Details
Main Authors:	Cao, Y, Eble, JM, Moon, EJ, Yuan, H, Weitzel, DH, Landon, CD, Yu-Chih Nien, C, Hanna, G, Rich, JN, Provenzale, JM, Dewhirst, MW
Format:	Journal article
Language:	English
Published:	American Association for Cancer Research 2013

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