Sequestration in Plasmodium falciparum malaria: sticky cells and sticky problems.
Plasmodium falciparum is unique among the human malarias in displaying the phenomenon of sequestration, in which mature infected erythrocytes adhere to post-capillary and capillary venular endothelium. In this review, Tony Berendt, David Ferguson and Chris Newbold describe the molecular and cellular...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1990
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| _version_ | 1797083446558851072 |
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| author | Berendt, A Ferguson, D Newbold, C |
| author_facet | Berendt, A Ferguson, D Newbold, C |
| author_sort | Berendt, A |
| collection | OXFORD |
| description | Plasmodium falciparum is unique among the human malarias in displaying the phenomenon of sequestration, in which mature infected erythrocytes adhere to post-capillary and capillary venular endothelium. In this review, Tony Berendt, David Ferguson and Chris Newbold describe the molecular and cellular biology of sequestration and cytoadherence. Potential host receptors identified to date that are expressed on endothelial cells (CD36, thrombospondin and ICAM-1) and the parasite-mediated changes in the infected erythrocyte (knob formation, senescence and the expression of parasite-derived neoantigens) are considered as well as the relevance of sequestration as a virulence factor in human disease and its potential role in parasite biology. |
| first_indexed | 2024-03-07T01:41:57Z |
| format | Journal article |
| id | oxford-uuid:972d8acf-37fe-4c07-8452-8ac524839498 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:41:57Z |
| publishDate | 1990 |
| record_format | dspace |
| spelling | oxford-uuid:972d8acf-37fe-4c07-8452-8ac5248394982022-03-26T23:57:38ZSequestration in Plasmodium falciparum malaria: sticky cells and sticky problems.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:972d8acf-37fe-4c07-8452-8ac524839498EnglishSymplectic Elements at Oxford1990Berendt, AFerguson, DNewbold, CPlasmodium falciparum is unique among the human malarias in displaying the phenomenon of sequestration, in which mature infected erythrocytes adhere to post-capillary and capillary venular endothelium. In this review, Tony Berendt, David Ferguson and Chris Newbold describe the molecular and cellular biology of sequestration and cytoadherence. Potential host receptors identified to date that are expressed on endothelial cells (CD36, thrombospondin and ICAM-1) and the parasite-mediated changes in the infected erythrocyte (knob formation, senescence and the expression of parasite-derived neoantigens) are considered as well as the relevance of sequestration as a virulence factor in human disease and its potential role in parasite biology. |
| spellingShingle | Berendt, A Ferguson, D Newbold, C Sequestration in Plasmodium falciparum malaria: sticky cells and sticky problems. |
| title | Sequestration in Plasmodium falciparum malaria: sticky cells and sticky problems. |
| title_full | Sequestration in Plasmodium falciparum malaria: sticky cells and sticky problems. |
| title_fullStr | Sequestration in Plasmodium falciparum malaria: sticky cells and sticky problems. |
| title_full_unstemmed | Sequestration in Plasmodium falciparum malaria: sticky cells and sticky problems. |
| title_short | Sequestration in Plasmodium falciparum malaria: sticky cells and sticky problems. |
| title_sort | sequestration in plasmodium falciparum malaria sticky cells and sticky problems |
| work_keys_str_mv | AT berendta sequestrationinplasmodiumfalciparummalariastickycellsandstickyproblems AT fergusond sequestrationinplasmodiumfalciparummalariastickycellsandstickyproblems AT newboldc sequestrationinplasmodiumfalciparummalariastickycellsandstickyproblems |