Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

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Tetrahydrobiopterin (BH4) is an essential cofactor for endothelial nitric oxide synthase (eNOS) function and NO generation. Augmentation of BH4 levels can prevent eNOS uncoupling and can improve endothelial dysfunction in vascular disease states. However, the physiological requirement for de novo en...

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Bibliographic Details
Main Authors:	Chuaiphichai, S, McNeill, E, Douglas, G, Crabtree, M, Bendall, J, Hale, AB, Alp, N, Channon, K
Format:	Journal article
Language:	English
Published:	2014

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