Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes
<p style="text-align:justify;">Dengue is the most prevalent arboviral disease of humans. The host and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defin...
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
National Academy of Sciences
2013
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| _version_ | 1826307867061256192 |
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| author | Nguyet, M Duong, T Trung, V Nguyen, T Tran, C Long, V Dui, L Nguyen, H Farrar, J Holmes, E Rabaa, M Bryant, J Nguyen, T Nguyen, H Nguyen, L Pham, M Nguyen, H Luong, T Wills, B Nguyen, C Wolbers, M Simmons, C |
| author_facet | Nguyet, M Duong, T Trung, V Nguyen, T Tran, C Long, V Dui, L Nguyen, H Farrar, J Holmes, E Rabaa, M Bryant, J Nguyen, T Nguyen, H Nguyen, L Pham, M Nguyen, H Luong, T Wills, B Nguyen, C Wolbers, M Simmons, C |
| author_sort | Nguyet, M |
| collection | OXFORD |
| description | <p style="text-align:justify;">Dengue is the most prevalent arboviral disease of humans. The host and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defined. The 50% mosquito infectious dose for each of DENV-1–4 ranged from 6.29 to 7.52 log10 RNA copies/mL of plasma. Increasing day of illness, declining viremia, and rising antibody titers were independently associated with reduced risk of DENV transmission. High early DENV plasma viremia levels in patients were a marker of the duration of human infectiousness, and blood meals containing high concentrations of DENV were positively associated with the prevalence of infectious mosquitoes 14 d after blood feeding. Ambulatory dengue cases had lower viremia levels compared with hospitalized dengue cases but nonetheless at levels predicted to be infectious to mosquitoes. These data define serotype-specific viremia levels that vaccines or drugs must inhibit to prevent DENV transmission.</p> |
| first_indexed | 2024-03-07T07:11:03Z |
| format | Journal article |
| id | oxford-uuid:9757e0a9-31c3-472e-8392-a24055fcddee |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:11:03Z |
| publishDate | 2013 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | oxford-uuid:9757e0a9-31c3-472e-8392-a24055fcddee2022-06-15T15:31:20ZHost and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9757e0a9-31c3-472e-8392-a24055fcddeeEnglishSymplectic Elements at OxfordNational Academy of Sciences2013Nguyet, MDuong, TTrung, VNguyen, TTran, CLong, VDui, LNguyen, HFarrar, JHolmes, ERabaa, MBryant, JNguyen, TNguyen, HNguyen, LPham, MNguyen, HLuong, TWills, BNguyen, CWolbers, MSimmons, C <p style="text-align:justify;">Dengue is the most prevalent arboviral disease of humans. The host and virus variables associated with dengue virus (DENV) transmission from symptomatic dengue cases (n = 208) to Aedes aegypti mosquitoes during 407 independent exposure events was defined. The 50% mosquito infectious dose for each of DENV-1–4 ranged from 6.29 to 7.52 log10 RNA copies/mL of plasma. Increasing day of illness, declining viremia, and rising antibody titers were independently associated with reduced risk of DENV transmission. High early DENV plasma viremia levels in patients were a marker of the duration of human infectiousness, and blood meals containing high concentrations of DENV were positively associated with the prevalence of infectious mosquitoes 14 d after blood feeding. Ambulatory dengue cases had lower viremia levels compared with hospitalized dengue cases but nonetheless at levels predicted to be infectious to mosquitoes. These data define serotype-specific viremia levels that vaccines or drugs must inhibit to prevent DENV transmission.</p> |
| spellingShingle | Nguyet, M Duong, T Trung, V Nguyen, T Tran, C Long, V Dui, L Nguyen, H Farrar, J Holmes, E Rabaa, M Bryant, J Nguyen, T Nguyen, H Nguyen, L Pham, M Nguyen, H Luong, T Wills, B Nguyen, C Wolbers, M Simmons, C Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes |
| title | Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes |
| title_full | Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes |
| title_fullStr | Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes |
| title_full_unstemmed | Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes |
| title_short | Host and viral features of human dengue cases shape the population of infected and infectious Aedes aegypti mosquitoes |
| title_sort | host and viral features of human dengue cases shape the population of infected and infectious aedes aegypti mosquitoes |
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