The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.

The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.

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Hypoxic and oxidant stresses can coexist in biological systems, and oxidant stress has been proposed to activate hypoxia pathways through the inactivation of the 'oxygen-sensing' hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases. Here, we show that despite reduced sensitiv...

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Détails bibliographiques
Auteurs principaux:	Masson, N, Singleton, R, Sekirnik, R, Trudgian, D, Ambrose, L, Miranda, M, Tian, Y, Kessler, B, Schofield, C, Ratcliffe, P
Format:	Journal article
Langue:	English
Publié:	2012

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