The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity.
Hypoxic and oxidant stresses can coexist in biological systems, and oxidant stress has been proposed to activate hypoxia pathways through the inactivation of the 'oxygen-sensing' hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases. Here, we show that despite reduced sensitiv...
| Những tác giả chính: | , , , , , , , , , |
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| Định dạng: | Journal article |
| Ngôn ngữ: | English |
| Được phát hành: |
2012
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The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
Được phát hành 2012
Journal article