Asymmetric Synthesis of Piperidines and Octahydroindolizines

The conjugate addition of a homochiral lithium amide to a ξ-hydroxy-α,β-unsaturated ester, followed by a one-pot, ring-closure-N-debenzylation protocol has been used in the asymmetric syntheses of (S)-coniine and (R)-δ-coniceine (isolated as the corresponding hydrochloride salts) and the bicyclic co...

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Váldodahkkit: Davies, S, Hughes, D, Price, P, Roberts, P, Russell, A, Smith, A, Thomson, J, Williams, O
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: 2010