Diagnostic and prognostic value of delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) in early osteoarthritis of the hip.
<h4>Background</h4> <p>Delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) can detect glycosaminoglycan loss in the acetabular cartilage of asymptomatic individuals with cam morphology. The aims of this study were to explore the relationship between cam morphology and dGEMRIC v...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2017
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| _version_ | 1797083550646796288 |
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| author | Palmer, A Fernquest, S Rombach, I Park, D Pollard, T Broomfield, J Bangerter, N Carr, A Glyn-Jones, S |
| author_facet | Palmer, A Fernquest, S Rombach, I Park, D Pollard, T Broomfield, J Bangerter, N Carr, A Glyn-Jones, S |
| author_sort | Palmer, A |
| collection | OXFORD |
| description | <h4>Background</h4> <p>Delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) can detect glycosaminoglycan loss in the acetabular cartilage of asymptomatic individuals with cam morphology. The aims of this study were to explore the relationship between cam morphology and dGEMRIC values, and to explore whether baseline dGEMRIC can predict the development of radiographic hip osteoarthritis.</p> <h4>Methods</h4> <p>Prospective cohort (SibKids) study with clinical, radiographic, and MRI assessment at baseline and five-year follow-up (n=34). The dGEMRIC values of cartilage regions were correlated with measures of cam morphology. ROC analysis was applied to baseline variables to predict radiographic loss of joint space width.</p> <h4>Results</h4> <p>Superoanterior acetabular cartilage dGEMRIC values were significantly lower in participants with cam morphology (p<0.001), defined as an alpha angle greater than 60 degrees. There was a negative correlation between alpha angle and the dGEMRIC value of adjacent acetabular cartilage. This relationship was strongest superoanteriorly (r=-0.697 p<0.001). There was a positive correlation between baseline dGEMRIC and the magnitude of joint space width narrowing (r=0.398 p=0.030). ROC analysis of combined baseline variables (positive impingement test, alpha angle, dGEMRIC ratio) gave an AUC of 0.75 for predicting joint space width narrowing greater than 0.5mm within five years.</p> <h4>Conclusions</h4> <p>The size and position of cam morphology determines the severity and location of progressive cartilage damage, supporting the biomechanical aetiology of this condition. Baseline dGEMRIC is able to predict the development of radiographic osteoarthritis. Compositional MRI offers the potential to identify patients who may benefit from early intervention to prevent the development of osteoarthritis.</p> |
| first_indexed | 2024-03-07T01:43:08Z |
| format | Journal article |
| id | oxford-uuid:978513c1-b44c-41d1-8aec-04fddfcbf7d6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:43:08Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:978513c1-b44c-41d1-8aec-04fddfcbf7d62022-03-27T00:00:22ZDiagnostic and prognostic value of delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) in early osteoarthritis of the hip.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:978513c1-b44c-41d1-8aec-04fddfcbf7d6EnglishSymplectic Elements at OxfordElsevier2017Palmer, AFernquest, SRombach, IPark, DPollard, TBroomfield, JBangerter, NCarr, AGlyn-Jones, S <h4>Background</h4> <p>Delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) can detect glycosaminoglycan loss in the acetabular cartilage of asymptomatic individuals with cam morphology. The aims of this study were to explore the relationship between cam morphology and dGEMRIC values, and to explore whether baseline dGEMRIC can predict the development of radiographic hip osteoarthritis.</p> <h4>Methods</h4> <p>Prospective cohort (SibKids) study with clinical, radiographic, and MRI assessment at baseline and five-year follow-up (n=34). The dGEMRIC values of cartilage regions were correlated with measures of cam morphology. ROC analysis was applied to baseline variables to predict radiographic loss of joint space width.</p> <h4>Results</h4> <p>Superoanterior acetabular cartilage dGEMRIC values were significantly lower in participants with cam morphology (p<0.001), defined as an alpha angle greater than 60 degrees. There was a negative correlation between alpha angle and the dGEMRIC value of adjacent acetabular cartilage. This relationship was strongest superoanteriorly (r=-0.697 p<0.001). There was a positive correlation between baseline dGEMRIC and the magnitude of joint space width narrowing (r=0.398 p=0.030). ROC analysis of combined baseline variables (positive impingement test, alpha angle, dGEMRIC ratio) gave an AUC of 0.75 for predicting joint space width narrowing greater than 0.5mm within five years.</p> <h4>Conclusions</h4> <p>The size and position of cam morphology determines the severity and location of progressive cartilage damage, supporting the biomechanical aetiology of this condition. Baseline dGEMRIC is able to predict the development of radiographic osteoarthritis. Compositional MRI offers the potential to identify patients who may benefit from early intervention to prevent the development of osteoarthritis.</p> |
| spellingShingle | Palmer, A Fernquest, S Rombach, I Park, D Pollard, T Broomfield, J Bangerter, N Carr, A Glyn-Jones, S Diagnostic and prognostic value of delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) in early osteoarthritis of the hip. |
| title | Diagnostic and prognostic value of delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) in early osteoarthritis of the hip. |
| title_full | Diagnostic and prognostic value of delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) in early osteoarthritis of the hip. |
| title_fullStr | Diagnostic and prognostic value of delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) in early osteoarthritis of the hip. |
| title_full_unstemmed | Diagnostic and prognostic value of delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) in early osteoarthritis of the hip. |
| title_short | Diagnostic and prognostic value of delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) in early osteoarthritis of the hip. |
| title_sort | diagnostic and prognostic value of delayed gadolinium enhanced magnetic resonance imaging of cartilage dgemric in early osteoarthritis of the hip |
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