In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology.
This report evaluates the role of interaction between glucocorticoid-induced tumor necrosis factor receptor (GITR) and GITR ligand (GITR-L) in the immuno-inflammatory response to infection with herpes simplex virus (HSV). Both GITR and GITR-L were transiently upregulated after ocular HSV infection,...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1797083576798281728 |
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| author | Suvas, S Kim, B Sarangi, P Tone, M Waldmann, H Rouse, B |
| author_facet | Suvas, S Kim, B Sarangi, P Tone, M Waldmann, H Rouse, B |
| author_sort | Suvas, S |
| collection | OXFORD |
| description | This report evaluates the role of interaction between glucocorticoid-induced tumor necrosis factor receptor (GITR) and GITR ligand (GITR-L) in the immuno-inflammatory response to infection with herpes simplex virus (HSV). Both GITR and GITR-L were transiently upregulated after ocular HSV infection, on antigen-specific T cells and antigen-presenting cells, respectively, in the draining lymph node (DLN). In addition, virus-specific T-cell responses in the DLN and spleen were enhanced by anti-GITR antibody treatment, an outcome expected to result in more severe inflammatory lesions. Intriguingly, the treatment resulted in significantly diminished T-cell-mediated ocular lesions. The explanation for these findings was that anti-GITR antibody treatment caused a reduced production of ocular MMP-9, a molecule involved in ocular angiogenesis, an essential step in the pathogenesis of herpetic keratitis. Our results are the first observations to determine in vivo kinetics of GITR and GITR-L expression after virus infection, and they emphasize the role of GITR-GITR-L interaction to regulate virus-induced immuno-inflammatory lesions. |
| first_indexed | 2024-03-07T01:43:26Z |
| format | Journal article |
| id | oxford-uuid:979c2695-93bd-4989-be53-e8c4d78eafdd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:43:26Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:979c2695-93bd-4989-be53-e8c4d78eafdd2022-03-27T00:01:05ZIn vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:979c2695-93bd-4989-be53-e8c4d78eafddEnglishSymplectic Elements at Oxford2005Suvas, SKim, BSarangi, PTone, MWaldmann, HRouse, BThis report evaluates the role of interaction between glucocorticoid-induced tumor necrosis factor receptor (GITR) and GITR ligand (GITR-L) in the immuno-inflammatory response to infection with herpes simplex virus (HSV). Both GITR and GITR-L were transiently upregulated after ocular HSV infection, on antigen-specific T cells and antigen-presenting cells, respectively, in the draining lymph node (DLN). In addition, virus-specific T-cell responses in the DLN and spleen were enhanced by anti-GITR antibody treatment, an outcome expected to result in more severe inflammatory lesions. Intriguingly, the treatment resulted in significantly diminished T-cell-mediated ocular lesions. The explanation for these findings was that anti-GITR antibody treatment caused a reduced production of ocular MMP-9, a molecule involved in ocular angiogenesis, an essential step in the pathogenesis of herpetic keratitis. Our results are the first observations to determine in vivo kinetics of GITR and GITR-L expression after virus infection, and they emphasize the role of GITR-GITR-L interaction to regulate virus-induced immuno-inflammatory lesions. |
| spellingShingle | Suvas, S Kim, B Sarangi, P Tone, M Waldmann, H Rouse, B In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. |
| title | In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. |
| title_full | In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. |
| title_fullStr | In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. |
| title_full_unstemmed | In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. |
| title_short | In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. |
| title_sort | in vivo kinetics of gitr and gitr ligand expression and their functional significance in regulating viral immunopathology |
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