Effective gene therapy with nonintegrating lentiviral vectors.

Effective gene therapy with nonintegrating lentiviral vectors.

Retroviral and lentiviral vector integration into host-cell chromosomes carries with it a finite chance of causing insertional mutagenesis. This risk has been highlighted by the induction of malignancy in mouse models, and development of lymphoproliferative disease in three individuals with severe c...

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Bibliographic Details
Main Authors: Yáñez-Muñoz, R, Balaggan, K, MacNeil, A, Howe, S, Schmidt, M, Smith, A, Buch, P, Maclaren, R, Anderson, P, Barker, SE, Duran, Y, Bartholomae, C, von Kalle, C, Heckenlively, JR, Kinnon, C, Ali, R, Thrasher, A
Format: Journal article
Language:English
Published: 2006

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