A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination
<p><strong>Background:</strong></p> <p>The evidence associating diet and risk of multiple sclerosis is inconclusive.</p> <p><strong>Objective:</strong></p> <p>We investigated associations between dietary patterns and risk of a first...
| Autori principali: | , , , , , , |
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| Altri autori: | |
| Natura: | Journal article |
| Lingua: | English |
| Pubblicazione: |
SAGE Publications
2018
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| _version_ | 1826286438243631104 |
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| author | Ausimmune Investigator Group Black, LJ Rowley, C Sherriff, J Pereira, G Ponsonby, A-L Lucas, RM |
| author2 | Dwyer, T |
| author_facet | Dwyer, T Ausimmune Investigator Group Black, LJ Rowley, C Sherriff, J Pereira, G Ponsonby, A-L Lucas, RM |
| author_sort | Ausimmune Investigator Group |
| collection | OXFORD |
| description | <p><strong>Background:</strong></p>
<p>The evidence associating diet and risk of multiple sclerosis is inconclusive.</p>
<p><strong>Objective:</strong></p>
<p>We investigated associations between dietary patterns and risk of a first clinical diagnosis of central nervous system demyelination, a common precursor to multiple sclerosis.</p>
<p><strong>Methods:</strong></p>
<p>We used data from the 2003–2006 Ausimmune Study, a case–control study examining environmental risk factors for a first clinical diagnosis of central nervous system demyelination, with participants matched on age, sex and study region. Using data from a food frequency questionnaire, dietary patterns were identified using principal component analysis. Conditional logistic regression models (n = 698, 252 cases, 446 controls) were adjusted for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, smoking, race, education, body mass index and dietary misreporting.</p>
<p><strong>Results:</strong></p>
<p>We identified two major dietary patterns – healthy (high in poultry, fish, eggs, vegetables, legumes) and Western (high in meat, full-fat dairy; low in wholegrains, nuts, fresh fruit, low-fat dairy), explaining 9.3% and 7.5% of variability in diet, respectively. A one-standard deviation increase in the healthy pattern score was associated with a 25% reduced risk of a first clinical diagnosis of central nervous system demyelination (adjusted odds ratio 0.75; 95% confidence interval 0.60, 0.94; p = 0.011). There was no statistically significant association between the Western dietary pattern and risk of a first clinical diagnosis of central nervous system demyelination.</p>
<p><strong>Conclusion:</strong></p>
<p>Following healthy eating guidelines may be beneficial for those at high risk of multiple sclerosis.</p> |
| first_indexed | 2024-03-07T01:43:46Z |
| format | Journal article |
| id | oxford-uuid:97b6f68f-973e-44f1-a37b-603133e3555c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:43:46Z |
| publishDate | 2018 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | oxford-uuid:97b6f68f-973e-44f1-a37b-603133e3555c2022-03-27T00:01:57ZA healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelinationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:97b6f68f-973e-44f1-a37b-603133e3555cEnglishSymplectic ElementsSAGE Publications2018Ausimmune Investigator GroupBlack, LJRowley, CSherriff, JPereira, GPonsonby, A-LLucas, RMDwyer, T<p><strong>Background:</strong></p> <p>The evidence associating diet and risk of multiple sclerosis is inconclusive.</p> <p><strong>Objective:</strong></p> <p>We investigated associations between dietary patterns and risk of a first clinical diagnosis of central nervous system demyelination, a common precursor to multiple sclerosis.</p> <p><strong>Methods:</strong></p> <p>We used data from the 2003–2006 Ausimmune Study, a case–control study examining environmental risk factors for a first clinical diagnosis of central nervous system demyelination, with participants matched on age, sex and study region. Using data from a food frequency questionnaire, dietary patterns were identified using principal component analysis. Conditional logistic regression models (n = 698, 252 cases, 446 controls) were adjusted for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, smoking, race, education, body mass index and dietary misreporting.</p> <p><strong>Results:</strong></p> <p>We identified two major dietary patterns – healthy (high in poultry, fish, eggs, vegetables, legumes) and Western (high in meat, full-fat dairy; low in wholegrains, nuts, fresh fruit, low-fat dairy), explaining 9.3% and 7.5% of variability in diet, respectively. A one-standard deviation increase in the healthy pattern score was associated with a 25% reduced risk of a first clinical diagnosis of central nervous system demyelination (adjusted odds ratio 0.75; 95% confidence interval 0.60, 0.94; p = 0.011). There was no statistically significant association between the Western dietary pattern and risk of a first clinical diagnosis of central nervous system demyelination.</p> <p><strong>Conclusion:</strong></p> <p>Following healthy eating guidelines may be beneficial for those at high risk of multiple sclerosis.</p> |
| spellingShingle | Ausimmune Investigator Group Black, LJ Rowley, C Sherriff, J Pereira, G Ponsonby, A-L Lucas, RM A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| title | A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| title_full | A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| title_fullStr | A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| title_full_unstemmed | A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| title_short | A healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
| title_sort | healthy dietary pattern associates with a lower risk of a first clinical diagnosis of central nervous system demyelination |
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