Formation of TCR dimers/trimers as a crucial step for T cell activation.
T cell activation involves specific interactions between the TCR and peptides presented by the MHC. This engagement leads to phosphorylation and subsequent internalization of the TCR complex. By analyzing the kinetics of the internalization of TCR, we found that the rate of TCR down-regulation was p...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1998
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| _version_ | 1826286442000678912 |
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| author | Bachmann, M Salzmann, M Oxenius, A Ohashi, P |
| author_facet | Bachmann, M Salzmann, M Oxenius, A Ohashi, P |
| author_sort | Bachmann, M |
| collection | OXFORD |
| description | T cell activation involves specific interactions between the TCR and peptides presented by the MHC. This engagement leads to phosphorylation and subsequent internalization of the TCR complex. By analyzing the kinetics of the internalization of TCR, we found that the rate of TCR down-regulation was proportional to the square of the TCR density. Mathematical modeling of TCR interactions indicates that such a relation is only possible if TCR dimerize before internalization. By mathematical analysis, our data would also be compatible with trimer but not larger oligomer formation. Thus, minimal TCR oligomerization is an essential step for peptide-mediated T cell activation. |
| first_indexed | 2024-03-07T01:43:50Z |
| format | Journal article |
| id | oxford-uuid:97bb9e2f-3339-4b5a-aa95-31310e4da44e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:43:50Z |
| publishDate | 1998 |
| record_format | dspace |
| spelling | oxford-uuid:97bb9e2f-3339-4b5a-aa95-31310e4da44e2022-03-27T00:02:06ZFormation of TCR dimers/trimers as a crucial step for T cell activation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:97bb9e2f-3339-4b5a-aa95-31310e4da44eEnglishSymplectic Elements at Oxford1998Bachmann, MSalzmann, MOxenius, AOhashi, PT cell activation involves specific interactions between the TCR and peptides presented by the MHC. This engagement leads to phosphorylation and subsequent internalization of the TCR complex. By analyzing the kinetics of the internalization of TCR, we found that the rate of TCR down-regulation was proportional to the square of the TCR density. Mathematical modeling of TCR interactions indicates that such a relation is only possible if TCR dimerize before internalization. By mathematical analysis, our data would also be compatible with trimer but not larger oligomer formation. Thus, minimal TCR oligomerization is an essential step for peptide-mediated T cell activation. |
| spellingShingle | Bachmann, M Salzmann, M Oxenius, A Ohashi, P Formation of TCR dimers/trimers as a crucial step for T cell activation. |
| title | Formation of TCR dimers/trimers as a crucial step for T cell activation. |
| title_full | Formation of TCR dimers/trimers as a crucial step for T cell activation. |
| title_fullStr | Formation of TCR dimers/trimers as a crucial step for T cell activation. |
| title_full_unstemmed | Formation of TCR dimers/trimers as a crucial step for T cell activation. |
| title_short | Formation of TCR dimers/trimers as a crucial step for T cell activation. |
| title_sort | formation of tcr dimers trimers as a crucial step for t cell activation |
| work_keys_str_mv | AT bachmannm formationoftcrdimerstrimersasacrucialstepfortcellactivation AT salzmannm formationoftcrdimerstrimersasacrucialstepfortcellactivation AT oxeniusa formationoftcrdimerstrimersasacrucialstepfortcellactivation AT ohaship formationoftcrdimerstrimersasacrucialstepfortcellactivation |